Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 15/20 | 0.59 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.42 |
| ▸ | NEK2 | P51955 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3944990 | 0.89 | TGFBR1 (0.62) | TGFBR1 | |
| SCHEMBL4166346 | 0.89 | TGFBR1 (0.65) | TGFBR1MAPK9MAPK10 | |
| SCHEMBL3949465 | 0.88 | TGFBR1 (0.61) | TGFBR1ROCK1 | |
| SCHEMBL3947619 | 0.88 | TGFBR1 (0.61) | TGFBR1 | |
| SCHEMBL3947614 | 0.87 | TGFBR1 (0.60) | TGFBR1ROCK1 | |
| SCHEMBL4170278 | 0.84 | TGFBR1 (0.50) | TGFBR1 | |
| SCHEMBL4178139 | 0.84 | TGFBR1 (0.53) | TGFBR1 | |
| SCHEMBL3952724 | 0.83 | TGFBR1 (0.55) | TGFBR1 | |
| SCHEMBL4171178 | 0.83 | TGFBR1 (0.55) | TGFBR1 | |
| SCHEMBL4181719 | 0.82 | TGFBR1 (0.55) | TGFBR1ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048269-A1 | CHEMICAL COMPOUNDS-821 | ASTRAZENECA AB (SE) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048269-A1 | CHEMICAL COMPOUNDS-821 | TGFBR1, TGFBR2, SMAD3 | TGFBR1 1/4885MAPK9 1235/4885MAPK10 1125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.