Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | STK17A | Q9UEE5 | 5/20 | 0.44 |
| ▸ | STK17B | O94768 | 3/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.38 |
| ▸ | LATS1 | O95835 | 1/20 | 0.36 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3447092 | 0.89 | KMT2A (0.50) | KMT2AMEN1STK17ASTK17BABL1 | |
| SCHEMBL30367077 | 0.84 | MEN1 (0.47) | KMT2AMEN1STK17ASTK17BL3MBTL1 | |
| SCHEMBL14422461 | 0.84 | STK17A (0.56) | KMT2AMEN1STK17ASTK17BL3MBTL1 | |
| SCHEMBL5152523 | 0.84 | STK17B (0.44) | KMT2AMEN1STK17ASTK17BNPSR1 | |
| SCHEMBL17162112 | 0.84 | MEN1 (0.47) | KMT2AMEN1STK17ASTK17BL3MBTL1 | |
| SCHEMBL1937548 | 0.84 | STK17A (0.54) | KMT2ASTK17ASTK17BNPSR1L3MBTL1 | |
| SCHEMBL13649077 | 0.83 | STK17B (0.43) | KMT2AMEN1STK17ASTK17BNPSR1 | |
| SCHEMBL3715848 | 0.83 | STK17A (0.61) | KMT2AMEN1STK17ASTK17B | |
| SCHEMBL5152648 | 0.83 | STK17B (0.45) | KMT2AMEN1STK17ASTK17BNPSR1 | |
| SCHEMBL3374448 | 0.82 | KMT2A (0.45) | KMT2AMEN1STK17ASTK17BTLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029145-A2 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | Novartis Ag (CH) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007140222-A2 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2007-12-06 | — | — | WO | disclosed |