SCHEMBL4189080

SCHEMBL4189080

Fc1ccc(CNc2cncc(-c3ccsc3)c2)cc1F

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP2 O95551 1/20 0.55
CYP2A6 P11509 6/20 0.49
PDGFRB P09619 3/20 0.42
PDGFRA P16234 3/20 0.42
MEN1 O00255 1/20 0.41
MAPT P10636 1/20 0.41
PABPC1 P11940 1/20 0.41
KMT2A Q03164 1/20 0.41
KCNH2 Q12809 1/20 0.38
ALPL P05186 1/20 0.38
CHEK2 O96017 1/20 0.38
FYN P06241 1/20 0.37
PRMT6 Q96LA8 1/20 0.37
CYP17A1 P05093 1/20 0.37
CYP11B1 P15538 1/20 0.37
CYP11B2 P19099 1/20 0.37
CTSC P53634 1/20 0.36
CYP2B6 P20813 2/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2C9 P11712 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4149001 0.84 MEN1 (0.48) TDP2MEN1MAPTPABPC1KMT2A
SCHEMBL4193131 0.83 MEN1 (0.46) MEN1MAPTPABPC1KMT2AKCNH2
SCHEMBL4187591 0.80 MEN1 (0.59) MEN1MAPTPABPC1KMT2AKCNH2
SCHEMBL4191983 0.80 MEN1 (0.43) MEN1MAPTPABPC1KMT2AKCNH2
SCHEMBL4140694 0.80 FYN (0.46) MEN1MAPTPABPC1KMT2AKCNH2
SCHEMBL4194238 0.79 FYN (0.55) TDP2CYP2A6MAPTKMT2ACHEK2
SCHEMBL4201069 0.79 CYP3A4 (0.54) TDP2CYP2A6MEN1MAPTPABPC1
SCHEMBL4182323 0.78 CLK1 (0.54) MEN1MAPTPABPC1KMT2AKCNH2
SCHEMBL4196785 0.78 FYN (0.62) TDP2CYP2A6PDGFRBPDGFRAKCNH2
SCHEMBL4189096 0.77 FYN (0.64) MEN1MAPTPABPC1KMT2AKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090196912-A1 Pyridinylamines GPC BOTECH AG (DE) 2009-08-06 US claimed
EP-1789393-A2 PYRIDINYLAMINES GPC Biotech AG (DE) 2007-05-30 EP claimed
WO-2006010637-A2 PYRIDINYLAMINES GPC BIOTECH AG (DE) 2006-02-02 WO claimed
US-20090196912-A1 Pyridinylamines GPC BOTECH AG (DE) 2009-08-06 US disclosed
EP-1789393-A2 PYRIDINYLAMINES GPC Biotech AG (DE) 2007-05-30 EP disclosed
WO-2006010637-A2 PYRIDINYLAMINES GPC BIOTECH AG (DE) 2006-02-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090196912-A1 Pyridinylamines PRNP, PLPBP, SNCA TDP2 135/4885CYP2A6 1615/4885PDGFRB 614/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.