Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefonicid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.99 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.76 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.76 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.76 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.76 |
| ▸ | PGR | P06401 | 1/20 | 0.76 |
| ▸ | PPARG | P37231 | 1/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 10/20 | 0.67 |
| ▸ | MAPT | P10636 | 9/20 | 0.67 |
| ▸ | POLB | P06746 | 9/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | APEX1 | P27695 | 1/20 | 0.67 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefonicid SCHEMBL27856008 | 1.00 | SLC6A4 (0.99) | SLC6A4SLC22A6SLC22A8SLC22A11NR1I2 | |
| Cefonicid SCHEMBL8425120 | 1.00 | SLC6A4 (0.99) | SLC6A4SLC22A6SLC22A8SLC22A11NR1I2 | |
| Cefonicid SCHEMBL16072827 | 0.99 | SLC6A4 (1.00) | SLC6A4SLC22A6SLC22A8SLC22A11NR1I2 | |
| Cefonicid SCHEMBL18048103 | 0.99 | SLC6A4 (1.00) | SLC6A4SLC22A6SLC22A8SLC22A11NR1I2 | |
| Cefonicid SCHEMBL60350 | 0.99 | SLC6A4 (1.00) | SLC6A4SLC22A6SLC22A8SLC22A11NR1I2 | |
| Cefonicid SCHEMBL13297839 | 0.99 | SLC6A4 (1.00) | SLC6A4SLC22A6SLC22A8SLC22A11NR1I2 | |
| Cefonicid SCHEMBL9080022 | 0.99 | SLC6A4 (1.00) | SLC6A4SLC22A6SLC22A8SLC22A11NR1I2 | |
| Cefonicid SCHEMBL537693 | 0.99 | SLC6A4 (1.00) | SLC6A4SLC22A6SLC22A8SLC22A11NR1I2 | |
| Cefonicid SCHEMBL28744041 | 0.99 | SLC6A4 (0.99) | SLC6A4SLC22A6SLC22A8SLC22A11NR1I2 | |
| Cefonicid SCHEMBL27865839 | 0.99 | SLC6A4 (0.99) | SLC6A4SLC22A6SLC22A8SLC22A11NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2615 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12274830-B2 | Nitric oxide inhalation therapy for infants with bronchiolitis | BEYOND AIR LTD (IL) | 2025-04-15 | — | — | US | claimed |
| US-20240173512-A1 | METHODS FOR POTENTIATING ANTIMICROBIAL AGENTS | STREETERVILLE CAPITAL, LLC | 2024-05-30 | — | — | US | claimed |
| US-11890421-B2 | Methods for potentiating antimicrobial agents | BEYOND AIR LTD (IL) | 2024-02-06 | — | — | US | claimed |
| CN-112912386-B | Cell penetrating peptides based on influenza virus M2 proteins | 中国医学科学院基础医学研究所 | 2023-10-20 | — | — | CN | claimed |
| CN-111072497-B | Method for recovering N, N' -dibenzylethylenediamine salt from ion exchange resin to be regenerated of cefonicid sodium | 华北制药河北华民药业有限责任公司 | 2022-10-25 | — | — | CN | claimed |
| US-20220169680-A1 | CELL-PENETRATING PEPTIDE BASED ON INFLUENZA VIRUS M2 PROTEIN | INSTITUTE OF BASIC MEDICAL SCIENCES CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2022-06-02 | — | — | US | claimed |
| EP-3912989-A1 | CELL-PENETRATING PEPTIDE BASED ON INFLUENZA VIRUS M2 PROTEIN | Institute of Basic Medical Sciences Chinese Academy of Medical Sciences (CN) | 2021-11-24 | — | — | EP | claimed |
| CN-113559264-A | Methods of treating microbial infections including mastitis | 罗达制药公司 | 2021-10-29 | — | — | CN | claimed |
| CN-113144197-A | Method of treating topical microbial infections | 罗达制药公司 | 2021-07-23 | — | — | CN | claimed |
| CN-112912386-A | Cell penetrating peptide based on influenza virus M2 protein | 中国医学科学院基础医学研究所 | 2021-06-04 | — | — | CN | claimed |
| US-20030064097-A1 | For delivery of drugs, nutrionals, cosmeceuticals and diagnostic agents | LIPOCINE INC. | 2003-04-03 | — | — | US | claimed |
| EP-1233756-A1 | SOLID CARRIERS FOR IMPROVED DELIVERY OF ACTIVE INGREDIENTS IN PHARMACEUTICAL COMPOSITIONS | Lipocine, Inc. (US) | 2002-08-28 | — | — | EP | claimed |
| US-20020107265-A1 | EMULSION COMPOSITIONS FOR POLYFUNCTIONAL ACTIVE INGREDIENTS | LIPOCINE INC. | 2002-08-08 | — | — | US | claimed |
| EP-1210063-A1 | COMPOSITIONS AND METHODS FOR ENHANCED ABSORPTION OF HYDROPHILIC THERAPEUTIC AGENTS | Lipocine, Inc. (US) | 2002-06-05 | — | — | EP | claimed |
| US-6309663-B1 | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents | LIPOCINE INC. | 2001-10-30 | — | — | US | claimed |
| US-6248363-B1 | Improved delivery of hydrophilic or hydrophobic pharmaceutical active ingredients, such as drugs, nutraceuticals, cosmeceuticals and diagnostic agents | LIPOCINE, INC. | 2001-06-19 | — | — | US | claimed |
| US-6245735-B1 | CONJUGATE OF ANTIBIOTIC AND POLYPEPTIDE OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR OR LIPOPOLYSACCHARIDE BINDING FRAGMENT | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2001-06-12 | — | — | US | claimed |
| WO-2001037808-A1 | SOLID CARRIERS FOR IMPROVED DELIVERY OF ACTIVE INGREDIENTS IN PHARMACEUTICAL COMPOSITIONS | LIPOCINE, INC. (US) | 2001-05-31 | — | — | WO | claimed |
| WO-2001028555-A1 | EMULSION COMPOSITIONS FOR POLYFUNCTIONAL ACTIVE INGREDIENTS | LIPOCINE, INC. (US) | 2001-04-26 | — | — | WO | claimed |
| WO-2001012155-A1 | COMPOSITIONS AND METHODS FOR ENHANCED ABSORPTION OF HYDROPHILIC THERAPEUTIC AGENTS | LIPOCINE, INC. (US) | 2001-02-22 | — | — | WO | claimed |