Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK9 | P45984 | 1/20 | 0.68 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | USP2 | O75604 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | BAP1 | Q92560 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | BCL2 | P10415 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4189472 | 0.86 | MAPK9 (0.72) | MAPK9MAPK10MEN1KMT2ARXFP1 | |
| SCHEMBL1518774 | 0.82 | MAPK9 (1.00) | MAPK9MAPK10MEN1KMT2ARXFP1 | |
| SCHEMBL4970920 | 0.79 | MAPK9 (0.77) | MAPK9MAPK10MEN1KMT2ARXFP1 | |
| SCHEMBL2425309 | 0.79 | MAPK9 (0.60) | MAPK9MAPK10MEN1KMT2AMAPT | |
| SCHEMBL2422850 | 0.79 | MAPK9 (0.75) | MAPK9MAPK10MEN1KMT2AMAPT | |
| SCHEMBL2420451 | 0.79 | MAPK9 (0.78) | MAPK9MAPK10MEN1KMT2ARXFP1 | |
| SCHEMBL2425303 | 0.79 | MAPK9 (0.78) | MAPK9MAPK10MEN1KMT2ARXFP1 | |
| SCHEMBL2420683 | 0.78 | MAPK9 (0.85) | MAPK9MAPK10MEN1KMT2ARXFP1 | |
| SCHEMBL7886289 | 0.78 | MAPK9 (0.65) | MAPK9MAPK10MEN1KMT2AMAPT | |
| SCHEMBL7447931 | 0.77 | MAPK9 (0.76) | MAPK9MAPK10MEN1KMT2ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2026802-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | Laboratoires Serono SA (CH) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007141224-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | LABORATOIRES SERONO SA (CH) | 2007-12-13 | — | — | WO | disclosed |