Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 3/20 | 0.36 |
| ▸ | GRM5 | P41594 | 7/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.33 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14036021 | 1.00 | PDE4A (0.40) | PDE4APDE4BPDE4CPDE4DPLA2G7 | |
| SCHEMBL14035891 | 0.89 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL14035848 | 0.89 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL13922757 | 0.88 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL4203246 | 0.85 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL4203245 | 0.85 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL14035847 | 0.85 | PDE4A (0.38) | PDE4APDE4BPDE4CPDE4DPLA2G7 | |
| SCHEMBL13923089 | 0.84 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL13922962 | 0.84 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL13923020 | 0.84 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841425-A4 | PHENYL-SUBSTITUTED PYRROLIDONES | IRM LLC A DELWARE LTD LIABILIT (BM) | 2009-02-18 | — | — | EP | disclosed |
| US-20080287516-A1 | Phenyl-Substituted Pyrrolidones | IRM LLC (BM) | 2008-11-20 | — | — | US | disclosed |
| EP-1841425-A2 | PHENYL-SUBSTITUTED PYRROLIDONES | IRM LLC A Delware Limited Liability Company (BM) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006081554-A2 | PHENYL-SUBSTITUTED PYRROLIDONES | IRM LLC (BM) | 2006-08-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287516-A1 | Phenyl-Substituted Pyrrolidones | MALT1, FKBP5, PREP | PDE4A 1181/4885PDE4B 1238/4885PDE4C 1261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.