Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 9/20 | 0.67 |
| ▸ | SRC | P12931 | 6/20 | 0.47 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.43 |
| ▸ | INPPL1 | O15357 | 2/20 | 0.38 |
| ▸ | INPP5A | Q14642 | 2/20 | 0.38 |
| ▸ | INPP5B | P32019 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12767507 | 0.80 | ERN1 (1.00) | ERN1 | |
| SCHEMBL8385853 | 0.80 | SRC (0.51) | ERN1SRCGPR84INPPL1INPP5A | |
| SCHEMBL4204715 | 0.79 | ERN1 (0.45) | ERN1SRCGPR84INPPL1INPP5A | |
| SCHEMBL27610136 | 0.79 | GPR84 (0.65) | ERN1SRCGPR84INPPL1INPP5A | |
| SCHEMBL10331756 | 0.76 | ERN1 (0.65) | ERN1 | |
| SCHEMBL30071644 | 0.74 | ERN1 (0.63) | ERN1 | |
| SCHEMBL31152504 | 0.74 | ERN1 (0.63) | ERN1 | |
| SCHEMBL2943970 | 0.74 | ERN1 (0.63) | ERN1 | |
| SCHEMBL4188304 | 0.73 | SRC (0.47) | ERN1SRCGPR84INPPL1INPP5A | |
| SCHEMBL4195560 | 0.73 | SRC (0.47) | ERN1SRCGPR84INPPL1INPP5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090137532-A1 | Aldolase-inhibiting aromatic compounds | VALORISATION-RECHERCHE, LIMITED PARTNERSHIP (CA) | 2009-05-28 | — | — | US | disclosed |
| US-7470821-B2 | Aldolase-inhibiting aromatic compounds | VALORISATION-RECHERCHE, LIMITED PARTNERSHIP (CA) | 2008-12-30 | — | — | US | disclosed |
| EP-1641807-B1 | AROMATIC COMPOUNDS AS ALDOLASE INHIBITORS | UNIV TOULOUSE (FR) | 2008-06-18 | — | — | EP | disclosed |
| US-20070043002-A1 | Aldolase-inhibiting aromatic compounds | UNIVERSITE PAUL SABATIER TOULOUSE III (FR) | 2007-02-22 | — | — | US | disclosed |
| EP-1641807-A2 | AROMATIC COMPOUNDS AS ALDOLASE INHIBITORS | UNIVERSITE PAUL SABATIER TOULOUSE III (FR) | 2006-04-05 | — | — | EP | disclosed |
| WO-2005012313-A2 | ALDOLASE-INHIBITING AROMATIC COMPOUNDS | UNIVERSITE PAUL SABATIER TOULOUSE III (FR) | 2005-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043002-A1 | Aldolase-inhibiting aromatic compounds | ALDOA, DERA, AKR1B1 | ERN1 2031/4885SRC 3453/4885GPR84 2546/4885 |
| US-20090137532-A1 | Aldolase-inhibiting aromatic compounds | ALDOA, DERA, AKR1B1 | ERN1 2031/4885SRC 3453/4885GPR84 2546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.