Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.71 |
| ▸ | TP53 | P04637 | 1/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3709855 | 1.00 | TSHR (0.71) | TSHRTP53CYP2D6RECQLALDH1A1 | |
| SCHEMBL2596611 | 0.92 | TSHR (0.78) | TSHRTP53CYP2D6RECQLALDH1A1 | |
| SCHEMBL23266974 | 0.92 | TSHR (0.78) | TSHRTP53CYP2D6RECQLALDH1A1 | |
| SCHEMBL2331470 | 0.92 | TSHR (0.78) | TSHRTP53CYP2D6RECQLALDH1A1 | |
| SCHEMBL341403 | 0.92 | TSHR (0.78) | TSHRTP53CYP2D6RECQLALDH1A1 | |
| Water SCHEMBL10705613 | 0.90 | TSHR (0.75) | TSHRTP53CYP2D6RECQLALDH1A1 | |
| Cadaverine Tartrate SCHEMBL16541102 | 0.88 | TSHR (0.85) | TSHRTP53CYP2D6RECQLALDH1A1 | |
| SCHEMBL7023442 | 0.86 | TP53 (0.51) | TSHRTP53CYP2D6RECQLALDH1A1 | |
| SCHEMBL11886503 | 0.84 | TSHR (1.00) | TSHRTP53CYP2D6RECQLALDH1A1 | |
| SCHEMBL223030 | 0.84 | TSHR (1.00) | TSHRTP53CYP2D6RECQLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029576-A1 | CYCLOHEXYLIMIDAZOLE LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | Eli Lilly & Company (US) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007124329-A1 | CYCLOHEXYLIMIDAZOLE LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-01 | — | — | WO | disclosed |