Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.30 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4190944 | 0.86 | MAPK14 (0.33) | MAPK14LCKCSF1R | |
| SCHEMBL4186193 | 0.81 | PDE4B (0.34) | — | |
| SCHEMBL4186181 | 0.81 | MCHR1 (0.30) | — | |
| SCHEMBL4184706 | 0.79 | — | — | |
| SCHEMBL1092474 | 0.79 | MAPK14 (0.31) | MAPK14LCKCSF1R | |
| SCHEMBL1092472 | 0.79 | MAPK14 (0.31) | MAPK14LCKCSF1R | |
| SCHEMBL4192647 | 0.78 | HRH3 (0.39) | — | |
| SCHEMBL4179199 | 0.76 | PDE5A (0.34) | — | |
| SCHEMBL4189000 | 0.75 | HRH3 (0.34) | — | |
| SCHEMBL4179209 | 0.70 | CHRM2 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021336-A2 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007127688-A2 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-08 | — | — | WO | disclosed |