Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | F7 | P08709 | 1/20 | 0.30 |
| ▸ | F11 | P03951 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4191491 | 0.86 | MAPK14 (0.32) | MAPK14LCKCSF1R | |
| SCHEMBL1093469 | 0.77 | MAPK14 (0.35) | MAPK14LCKCSF1RF7F11 | |
| SCHEMBL1093467 | 0.77 | MAPK14 (0.35) | MAPK14LCKCSF1RF7F11 | |
| SCHEMBL4181628 | 0.77 | — | — | |
| SCHEMBL4196923 | 0.75 | HPGD (0.42) | — | |
| SCHEMBL4185003 | 0.73 | PDE5A (0.34) | — | |
| SCHEMBL4183670 | 0.72 | SPR (0.34) | — | |
| SCHEMBL4180585 | 0.70 | S1PR5 (0.40) | — | |
| SCHEMBL1092474 | 0.69 | MAPK14 (0.31) | MAPK14LCKCSF1R | |
| SCHEMBL1092472 | 0.69 | MAPK14 (0.31) | MAPK14LCKCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021336-A2 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007127688-A2 | INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-08 | — | — | WO | disclosed |