Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.89 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL430711 | 1.00 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL4727295 | 1.00 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL7921325 | 1.00 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL9244607 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL10529415 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL9405453 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL10427586 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL397502 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL28946456 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL237100 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 5555 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122075745-A | Signal probe with CT and MRI imaging functions and preparation method and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122075317-A | Bismuth microsphere oral care agent for eliminating halitosis, resisting inflammation and inhibiting bacteria | — | 2026-05-26 | — | — | CN | claimed |
| US-12630758-B2 | Downhole methods and compositions used in such | DORF KETAL CHEMICALS FZE (AE) | 2026-05-19 | — | — | US | claimed |
| CN-122039125-A | Wood-derived carbon self-supporting transition metal core-shell hydrogen evolution catalyst and preparation method thereof | 广西大学 | 2026-05-15 | — | — | CN | claimed |
| CN-122010174-A | One-dimensional mesoporous bismuth oxide nanorod constructed based on spherical mesopores and preparation method thereof | 内蒙古大学 | 2026-05-12 | — | — | CN | claimed |
| WO-2026089857-A1 | METHOD OF PREPARING AND USING A SKIN CARE COMPOSITION | DOW SILICONES CORPORATION (US) | 2026-04-30 | — | — | WO | claimed |
| WO-2026089856-A1 | METHOD OF PREPARING AND USING A SKIN CARE FORMULATION | DOW SILICONES CORPORATION (US) | 2026-04-30 | — | — | WO | claimed |
| EP-4061326-B1 | PERSONAL CARE COMPOSITION COMPRISING A MULTISTAGE POLYMER | DOW GLOBAL TECHNOLOGIES LLC (US) | 2026-02-25 | — | — | EP | claimed |
| EP-4688909-A1 | POLYESTER ELASTOMERS FROM DI-CARBOXYLIC ACID OR TRI-CARBOXYLIC ACID, MONO-CARBOXYLIC ACID, AND POLYOL FOR COSMETIC AND PERSONAL CARE APPLICATIONS | Momentive Performance Materials Inc. (US) | 2026-02-11 | — | — | EP | claimed |
| EP-4678725-A1 | CO-GRANULES COMPRISING BLEACHING CATALYST, BLEACHING ACTIVATOR, BINDER AND ZINC OR BISMUTH SALT, AND BLEACHING AND CLEANING AGENT COMPRISING SAME | Catexel GmbH (DE) | 2026-01-14 | — | — | EP | claimed |
| EP-0206626-A2 | Use of Bismuth for the manufacture of a medicament for the treatment of gastrointestinal disorders induced by Campylobacter polyridis | Marshall, Barry James, Dr. (US) | 1986-12-30 | — | — | EP | claimed |
| US-4583986-A | USING CATALYST WITH HIGH WATER SOLUBILITY AND LOW MOLECULAR WEIGHT | COMBE INCORPORATED (US) | 1986-04-22 | — | — | US | claimed |
| EP-0075992-B1 | BISMUTH CONTAINING COMPOSITION AND METHOD FOR THE PREPARATION THEREOF | GIST-BROCADES N.V. (NL) | 1985-09-18 | — | — | EP | claimed |
| US-4501923-A | Process for preparing adrenochrome | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1985-02-26 | — | — | US | claimed |
| EP-0075992-A1 | Bismuth containing composition and method for the preparation thereof | GIST-BROCADES N.V. (NL) | 1983-04-06 | — | — | EP | claimed |
| WO-1983001001-A1 | BISMUTH CONTAINING COMPOSITION AND METHOD FOR THE PREPARATION THEREOF | GIST BROCADES NV (NL) | 1983-03-31 | — | — | WO | claimed |
| US-4252618-A | ALKALI METAL STANNATE, BISMUTH CITRATE | PITT METALS & CHEMICALS, INC. (US) | 1981-02-24 | — | — | US | claimed |
| US-4093649-A | Liquid phase oxidation of unsaturated aldehydes to carboxylic acids with a bismuth catalyst | ATLANTIC RICHFIELD COMPANY (US) | 1978-06-06 | — | — | US | claimed |
| US-4067974-A | Stabilized solid form choline salicylate compositions | THE PURDUE FREDERICK COMPANY (US) | 1978-01-10 | — | — | US | claimed |
| US-3954393-A | Hair dyeing composition containing bismuth citrate, triethanolamine and sulfur | COMBE, INC. (US) | 1976-05-04 | — | — | US | claimed |