Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 11/20 | 1.00 |
| ▸ | GRIN2B | Q13224 | 11/20 | 1.00 |
| ▸ | GRIN2D | O15399 | 2/20 | 1.00 |
| ▸ | GRIN2A | Q12879 | 2/20 | 1.00 |
| ▸ | GRIN2C | Q14957 | 2/20 | 1.00 |
| ▸ | GABRP | O00591 | 2/20 | 0.65 |
| ▸ | GABRD | O14764 | 2/20 | 0.65 |
| ▸ | G6PD | P11413 | 2/20 | 0.65 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.65 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.65 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.65 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.65 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.65 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.65 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.65 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.65 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.65 |
| ▸ | GABRE | P78334 | 2/20 | 0.65 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.65 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL783064 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2BGRIN2DGRIN2AGRIN2C | |
| SCHEMBL6377561 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2BGRIN2DGRIN2AGRIN2C | |
| SCHEMBL19281748 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2BGRIN2DGRIN2AGRIN2C | |
| SCHEMBL782131 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2BGRIN2DGRIN2AGRIN2C | |
| SCHEMBL782132 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2BGRIN2DGRIN2AGRIN2C | |
| SCHEMBL24703701 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2BGRIN2DGRIN2AGRIN2C | |
| SCHEMBL4198024 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2BGRIN2DGRIN2AGRIN2C | |
| SCHEMBL8075513 | 1.00 | GRIN1 (1.00) | GRIN1GRIN2BGRIN2DGRIN2AGRIN2C | |
| SCHEMBL783063 | 0.92 | GRIN1 (0.85) | GRIN1GRIN2BGRIN2DGRIN2AGRIN2C | |
| SCHEMBL17544405 | 0.90 | GRIN1 (1.00) | GRIN1GRIN2BGRIN2DGRIN2AGRIN2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6083941-A | TREATMENT OF NEUROPATHIC PAIN, DRUG WITHDRAWAL/DEPENDENCY, EPILEPSY, GLAUCOMA, CHRONIC NEURODEGENERATIVE DISEASES, AMYOTROPHIC LATERAL SCLEROSIS, ANXIETY DISORDERS, BRAIN CELL DEATH, ISCHAEMIA, STROKE, TRAUMA | TRUSTEES OF BOSTON UNIVERSITY (US) | 2000-07-04 | — | — | US | claimed |
| US-20230218638-A1 | NEUROACTIVE COMPOUNDS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS, INC. | 2023-07-13 | — | — | US | disclosed |
| US-20170304321-A1 | NEUROACTIVE COMPOUNDS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS INC (US) | 2017-10-26 | — | — | US | disclosed |
| US-20170304321-A1 | NEUROACTIVE COMPOUNDS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS INC (US) | 2017-10-26 | — | — | US | disclosed |
| EP-1212618-B1 | EFFECT OF STEROIDS ON NMDA RECEPTORS DEPENDS ON SUBUNIT COMPOSITION | UNIV BOSTON (US) | 2009-03-11 | — | — | EP | disclosed |
| US-20040204490-A1 | Effect of steroids on NMDA receptors depends on subunit composition | TRUSTEES OF BOSTON UNIVERSITY | 2004-10-14 | — | — | US | disclosed |
| US-6623933-B1 | Contacting with neurotransmitter recognition site ligand in the presence and absence of a steroid-based molecule; chimeric isoform; use in treating neurological disorders including ischemic stroke, epilepsy and schizophrenia | TRUSTEES OF BOSTON UNIVERSITY | 2003-09-23 | — | — | US | disclosed |
| US-6083941-A | TREATMENT OF NEUROPATHIC PAIN, DRUG WITHDRAWAL/DEPENDENCY, EPILEPSY, GLAUCOMA, CHRONIC NEURODEGENERATIVE DISEASES, AMYOTROPHIC LATERAL SCLEROSIS, ANXIETY DISORDERS, BRAIN CELL DEATH, ISCHAEMIA, STROKE, TRAUMA | TRUSTEES OF BOSTON UNIVERSITY (US) | 2000-07-04 | — | — | US | disclosed |
| US-5888996-A | ANTICONVULSANTS | TRUSTEES OF BOSTON UNIVERSITY (US) | 1999-03-30 | — | — | US | disclosed |
| EP-0840612-A1 | INHIBITION OF NMDA RECEPTOR ACTIVITY BY PREGNENOLONE SULFATE DERIVATIVES | TRUSTEES OF BOSTON UNIVERSITY (US) | 1998-05-13 | — | — | EP | disclosed |
| WO-1997003677-A1 | INHIBITION OF NMDA RECEPTOR ACTIVITY BY PREGNENOLONE SULFATE DERIVATIVES | TRUSTEES OF BOSTON UNIVERSITY (US) | 1997-02-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204490-A1 | Effect of steroids on NMDA receptors depends on subunit composition | GRIN3B, GRIN1, GRIN3A | GRIN1 2/4885GRIN2B 6/4885GRIN2D 23/4885 |
| US-20230218638-A1 | NEUROACTIVE COMPOUNDS AND METHODS OF USE THEREOF | GRIN3B, GRIN2A, GRIN1 | GRIN1 3/4885GRIN2B 5/4885GRIN2D 16/4885 |
| US-20170304321-A1 | NEUROACTIVE COMPOUNDS AND METHODS OF USE THEREOF | GRIN3B, GRIN2A, GRIN1 | GRIN1 3/4885GRIN2B 5/4885GRIN2D 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.