SCHEMBL4192048

SCHEMBL4192048

CC1(C)CCC(C)(C)c2cc3c(I)cc(-c4ccc(C(=O)O)cc4)cc3cc21

nearest known ligand 0.67

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
RARB P10826 13/20 0.67
RARG P13631 13/20 0.67
RARA P10276 11/20 0.67
RXRA P19793 10/20 0.53
RXRB P28702 2/20 0.53
RXRG P48443 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9049761 0.86 RARB (0.69) RARBRARGRARARXRARXRB
SCHEMBL9054209 0.86 RARG (0.69) RARBRARGRARARXRARXRB
SCHEMBL9050626 0.86 RARB (0.69) RARBRARGRARARXRARXRB
SCHEMBL9049859 0.84 RARB (0.66) RARBRARGRARARXRARXRB
SCHEMBL9048881 0.84 RARB (0.66) RARBRARGRARARXRARXRB
SCHEMBL9050845 0.82 RARB (0.64) RARBRARGRARARXRARXRB
SCHEMBL9051345 0.81 RARB (0.63) RARBRARGRARARXRARXRB
SCHEMBL31266609 0.81 RARB (1.00) RARBRARGRARARXRARXRB
SCHEMBL3453631 0.81 RARB (1.00) RARBRARGRARARXRARXRB
SCHEMBL9051350 0.81 RARB (0.62) RARBRARGRARARXRARXRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7501487-B1 Retinoid receptor compositions and methods THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2009-03-10 US disclosed
EP-0514488-B1 RETINOID RECEPTOR COMPOSITIONS AND METHODS SALK INST FOR BIOLOGICAL STUDI (US) 2000-09-13 EP disclosed
EP-0999271-A2 Retinoid receptor compositions and methods THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 2000-05-10 EP disclosed
US-5723329-A POLYPEPTIDES THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 1998-03-03 US disclosed
EP-0514488-A4 RETINOID RECEPTOR COMPOSITIONS AND METHODS 1993-02-17 EP disclosed
EP-0514488-A1 RETINOID RECEPTOR COMPOSITIONS AND METHODS THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 1992-11-25 EP disclosed
WO-1991012258-A1 RETINOID RECEPTOR COMPOSITIONS AND METHODS THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) 1991-08-22 WO disclosed