Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 16/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4185478 | 0.76 | CSF1R (0.52) | CSF1RKITHDAC3HDAC1HDAC2 | |
| SCHEMBL4187849 | 0.73 | ACACB (0.41) | — | |
| SCHEMBL3909606 | 0.70 | PLA2G10 (0.41) | CSF1R | |
| SCHEMBL4189535 | 0.69 | PLA2G10 (0.38) | CSF1R | |
| SCHEMBL3902640 | 0.67 | PLA2G10 (0.41) | CSF1RHDAC1HDAC2 | |
| Hydrochloric Acid SCHEMBL11675533 | 0.67 | NOS3 (0.56) | — | |
| SCHEMBL4187992 | 0.67 | GRM2 (0.39) | CSF1RKIT | |
| SCHEMBL3083546 | 0.66 | CSF1R (0.60) | CSF1RKIT | |
| SCHEMBL3440766 | 0.66 | NOS3 (0.57) | — | |
| SCHEMBL3903567 | 0.64 | GRM2 (0.39) | CSF1RKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2021329-A1 | INHIBITORS OF C-FMS KINASE | Janssen Pharmaceutica, N.V. (BE) | 2009-02-11 | — | — | EP | disclosed |
| WO-2007124318-A1 | INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-01 | — | — | WO | disclosed |