SCHEMBL4192928

SCHEMBL4192928

O=C(C(=O)c1ccc(Oc2ccccc2C(=O)C(=O)c2cc(C#Cc3ccccc3)cc(C#Cc3ccccc3)c2)cc1)c1ccc(Oc2ccccc2C(=O)C(=O)c2cc(C#Cc3ccccc3)cc(C#Cc3ccccc3)c2)cc1

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CTNNB1 P35222 1/20 0.43
MAPT P10636 1/20 0.40
FFAR1 O14842 1/20 0.39
CES2 O00748 1/20 0.39
CES1 P23141 1/20 0.39
KDM4E B2RXH2 2/20 0.38
POLB P06746 2/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
TTR P02766 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.37
HAO1 Q9UJM8 1/20 0.37
MAPK14 Q16539 1/20 0.37
PARP10 Q53GL7 1/20 0.37
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
AKR1C2 P52895 1/20 0.36
AKR1C1 Q04828 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5533189 0.86 FFAR1 (0.49) FFAR1CES2CES1POLBHAO1
SCHEMBL10782271 0.81 NPC1 (0.40) CTNNB1MAPTFFAR1CES2CES1
SCHEMBL10626515 0.81 HAO1 (0.40) CTNNB1MAPTFFAR1CES2CES1
SCHEMBL5535660 0.80 FFAR1 (0.40) FFAR1CES2CES1POLBMEN1
SCHEMBL4193823 0.79 CTNNB1 (0.45) CTNNB1MAPTCES2CES1KDM4E
Benzil SCHEMBL6674970 0.79 CES2 (0.58) CTNNB1CES2CES1POLBTTR
SCHEMBL27546791 0.79 CES2 (0.56) CTNNB1MAPTCES2CES1MEN1
SCHEMBL11508105 0.78 CTNNB1 (0.62) CTNNB1MAPTCES2CES1MEN1
SCHEMBL13567253 0.78 FFAR1 (0.56) FFAR1CES2CES1HAO1PARP10
SCHEMBL13567255 0.78 FFAR1 (0.56) FFAR1CES2CES1HAO1PARP10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1476416-B1 MULTIFUNCTIONAL MONOMERS AND THEIR USE IN MAKING CROSS-LINKED POLYMERS AND POROUS FILMS DOW GLOBAL TECHNOLOGIES LLC (US) 2015-12-30 EP disclosed
US-7635741-B2 Curable polyacetylenes used as dielectrics in making microelectronics such as integrated circuits DOW GLOBAL TECHNOLOGIES INC. 2009-12-22 US disclosed
EP-1476416-A2 MULTIFUNCTIONAL MONOMERS AND THEIR USE IN MAKING CROSS-LINKED POLYMERS AND POROUS FILMS DOW GLOBAL TECHNOLOGIES INC. (US) 2004-11-17 EP disclosed
US-20040053033-A1 Multifunctional monomers and their use in making cross-linked polymers and porous films NIU Q JASON (US) 2004-03-18 US disclosed
WO-2003068825-A2 MULTIFUNCTIONAL MONOMERS AND THEIR USE IN MAKING CROSS-LINKED POLYMERS AND POROUS FILMS DOW GLOBAL TECHNOLOGIES INC. (US) 2003-08-21 WO disclosed