Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23231710 | 0.85 | ALDH1A1 (0.55) | ALDH1A1LMNAMEN1KMT2APKM | |
| SCHEMBL30919794 | 0.85 | ALDH1A1 (0.55) | ALDH1A1LMNAMEN1KMT2APKM | |
| SCHEMBL23722370 | 0.85 | ALDH1A1 (0.55) | ALDH1A1LMNAMEN1KMT2APKM | |
| SCHEMBL9616977 | 0.83 | ALDH1A1 (0.54) | ALDH1A1LMNAMEN1KMT2APKM | |
| SCHEMBL639774 | 0.80 | ALDH1A1 (0.51) | ALDH1A1LMNAMEN1KMT2APKM | |
| SCHEMBL30814823 | 0.80 | ALDH1A1 (0.51) | ALDH1A1LMNAMEN1KMT2APKM | |
| SCHEMBL2425379 | 0.80 | ALDH1A1 (0.51) | ALDH1A1LMNAMEN1KMT2APKM | |
| SCHEMBL2486876 | 0.79 | ALDH1A1 (0.54) | ALDH1A1LMNAMEN1KMT2APKM | |
| SCHEMBL42581 | 0.78 | OPRL1 (0.52) | POLBOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL4197025 | 0.78 | CHRM2 (0.36) | ALDH1A1LMNAMEN1KMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090062291-A1 | PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. | 2009-03-05 | — | — | US | disclosed |
| US-20090062277-A1 | PHOSPHODIESTERASE 10 INHIBITORS | AMGEN INC. | 2009-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062291-A1 | PHOSPHODIESTERASE 10 INHIBITORS | PDE10A, PDE12, PDE5A | ALDH1A1 777/4885LMNA 4592/4885MEN1 2867/4885 |
| US-20090062277-A1 | PHOSPHODIESTERASE 10 INHIBITORS | PDE5A, PDE12, PDE10A | ALDH1A1 936/4885LMNA 4552/4885MEN1 2752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.