Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | WRN | Q14191 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 9/20 | 0.51 |
| ▸ | FLT3 | P36888 | 8/20 | 0.51 |
| ▸ | KIT | P10721 | 6/20 | 0.51 |
| ▸ | BRAF | P15056 | 6/20 | 0.51 |
| ▸ | CSF1R | P07333 | 5/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.51 |
| ▸ | FLT1 | P17948 | 5/20 | 0.51 |
| ▸ | RET | P07949 | 4/20 | 0.51 |
| ▸ | FRK | P42685 | 4/20 | 0.51 |
| ▸ | CAMK2D | Q13557 | 4/20 | 0.51 |
| ▸ | NTRK3 | Q16288 | 4/20 | 0.51 |
| ▸ | HIPK4 | Q8NE63 | 4/20 | 0.51 |
| ▸ | PLK4 | O00444 | 4/20 | 0.51 |
| ▸ | AURKA | O14965 | 4/20 | 0.51 |
| ▸ | ABL1 | P00519 | 4/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.51 |
| ▸ | LCK | P06239 | 4/20 | 0.51 |
| ▸ | FYN | P06241 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4195622 | 0.91 | BRAF (0.59) | BLMKDRFLT3KITBRAF | |
| SCHEMBL4188378 | 0.88 | BRAF (0.57) | KDRFLT3KITBRAFCSF1R | |
| SCHEMBL4205668 | 0.86 | KDR (0.63) | KDRFLT3KITBRAFCSF1R | |
| SCHEMBL4195736 | 0.85 | KDR (0.67) | KDRFLT3KITCSF1RFGFR1 | |
| SCHEMBL3977510 | 0.83 | BRAF (0.66) | BLMWRNKDRFLT3BRAF | |
| SCHEMBL4205675 | 0.83 | KIT (0.64) | KDRFLT3KITBRAFCSF1R | |
| SCHEMBL4195360 | 0.80 | BRAF (0.71) | KDRBRAFPDGFRB | |
| SCHEMBL4192298 | 0.74 | BRAF (0.53) | KDRBRAFCSF1R | |
| SCHEMBL4196519 | 0.74 | BRAF (0.65) | BLMKDRBRAFMINK1BTK | |
| SCHEMBL4656768 | 0.72 | BRAF (0.68) | BRAFRIPK1EPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118276-A1 | THIENOPYRIMIDINES, THIENOPYRIDINES, AND PYRROLOPYRIMIDINES AS B-RAF INHIBITORS | WYETH (US) | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118276-A1 | THIENOPYRIMIDINES, THIENOPYRIDINES, AND PYRROLOPYRIMIDINES AS B-RAF INHIBITORS | BRAF, ARAF, RAF1 | BLM 2054/4885WRN 748/4885KDR 616/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.