Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.63 |
| ▸ | CNR1 | P21554 | 10/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.55 |
| ▸ | FLT3 | P36888 | 5/20 | 0.55 |
| ▸ | KIT | P10721 | 5/20 | 0.55 |
| ▸ | PLK4 | O00444 | 4/20 | 0.55 |
| ▸ | AURKA | O14965 | 4/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.55 |
| ▸ | LCK | P06239 | 4/20 | 0.55 |
| ▸ | CSF1R | P07333 | 4/20 | 0.55 |
| ▸ | LYN | P07948 | 4/20 | 0.55 |
| ▸ | RET | P07949 | 4/20 | 0.55 |
| ▸ | FLT1 | P17948 | 4/20 | 0.55 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.55 |
| ▸ | AXL | P30530 | 4/20 | 0.55 |
| ▸ | FLT4 | P35916 | 4/20 | 0.55 |
| ▸ | FRK | P42685 | 4/20 | 0.55 |
| ▸ | CLK2 | P49760 | 4/20 | 0.55 |
| ▸ | BLK | P51451 | 4/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4195736 | 0.93 | KDR (0.67) | KDRCNR1FGFR1FLT3KIT | |
| SCHEMBL4205675 | 0.88 | KIT (0.64) | KDRFGFR1FLT3KITPLK4 | |
| SCHEMBL4195622 | 0.87 | BRAF (0.59) | KDRFGFR1FLT3KITPLK4 | |
| SCHEMBL4194989 | 0.86 | BLM (0.54) | KDRFGFR1FLT3KITPLK4 | |
| SCHEMBL4188378 | 0.85 | BRAF (0.57) | KDRFGFR1FLT3KITPLK4 | |
| SCHEMBL4192298 | 0.82 | BRAF (0.53) | KDRCSF1RBRAF | |
| SCHEMBL4198556 | 0.82 | CNR1 (0.62) | CNR1TEKCNR2BRAF | |
| SCHEMBL4199921 | 0.78 | MEN1 (0.56) | KDRCSF1RABL1JAK3BRAF | |
| SCHEMBL30469267 | 0.77 | CNR1 (1.00) | CNR1CNR2 | |
| SCHEMBL20557649 | 0.77 | CNR1 (1.00) | CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118276-A1 | THIENOPYRIMIDINES, THIENOPYRIDINES, AND PYRROLOPYRIMIDINES AS B-RAF INHIBITORS | WYETH (US) | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118276-A1 | THIENOPYRIMIDINES, THIENOPYRIDINES, AND PYRROLOPYRIMIDINES AS B-RAF INHIBITORS | BRAF, ARAF, RAF1 | KDR 616/4885CNR1 2694/4885FGFR1 172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.