Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | FPR2 | P25090 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27752231 | 0.87 | SMN1; SMN2 (0.47) | SMN1; SMN2KMT2APOLBMEN1MAPT | |
| SCHEMBL4197579 | 0.78 | HTR2A (0.48) | POLBFPR2 | |
| SCHEMBL4031169 | 0.78 | NR1I2 (0.50) | SMN1; SMN2BACE1KMT2APOLBMEN1 | |
| SCHEMBL4198685 | 0.77 | PARP1 (0.62) | SMN1; SMN2KMT2APOLBMEN1MAPT | |
| SCHEMBL834779 | 0.77 | MEN1 (0.45) | KMT2APOLBMEN1MAPTALDH1A1 | |
| SCHEMBL4190340 | 0.75 | FPR2 (0.43) | POLBMAPTALDH1A1FPR2 | |
| SCHEMBL834075 | 0.73 | USP30 (0.47) | SMN1; SMN2KMT2AMEN1MAPTALDH1A1 | |
| SCHEMBL1875466 | 0.72 | PARP1 (0.59) | SMN1; SMN2KMT2APOLBMEN1MAPT | |
| SCHEMBL20986710 | 0.71 | FPR2 (0.46) | POLBFPR2 | |
| SCHEMBL20986860 | 0.71 | FPR2 (0.46) | POLBFPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029535-A1 | ISOINDOLE DERIVATIVES USEFUL FOR TREATING PAIN, GASTROINTESTINAL DISEASES AND CANCER | AstraZeneca AB (SE) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007139464-A1 | ISOINDOLE DERIVATIVES USEFUL FOR TREATING PAIN, GASTROINTESTINAL DISEASES AND CANCER | ASTRAZENECA AB (SE) | 2007-12-06 | — | — | WO | disclosed |
| WO-2007139464-A1 | ISOINDOLE DERIVATIVES USEFUL FOR TREATING PAIN, GASTROINTESTINAL DISEASES AND CANCER | ASTRAZENECA AB (SE) | 2007-12-06 | — | — | WO | disclosed |