Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 7/20 | 0.61 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1388588 | 0.86 | DHFR (0.59) | DHFRFGFR1SRCMAPTADORA1 | |
| SCHEMBL168973 | 0.79 | SCN2A (0.57) | DHFRFGFR1SRCSCN10AADORA1 | |
| SCHEMBL30413525 | 0.79 | SCN2A (0.57) | DHFRFGFR1SRCSCN10AADORA1 | |
| SCHEMBL4186547 | 0.79 | DHFR (0.56) | DHFRFGFR1SRCSCN10AADORA1 | |
| SCHEMBL1388506 | 0.77 | DHFR (0.67) | DHFRMEN1HTTKMT2A | |
| SCHEMBL29913206 | 0.77 | DHFR (0.67) | DHFRMEN1HTTKMT2A | |
| SCHEMBL1388267 | 0.76 | DHFR (1.00) | DHFRFGFR1SRCADORA1ADORA2A | |
| SCHEMBL263262 | 0.75 | SCN10A (0.56) | HTR2BPDE4DSCN10AMEN1MAPT | |
| SCHEMBL1388562 | 0.75 | DHFR (1.00) | DHFRFGFR1SRCADORA1ADORA2A | |
| SCHEMBL29913330 | 0.75 | DHFR (1.00) | DHFRFGFR1SRCADORA1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032543-A1 | 2-ANILINO-4-AMINOALKYLENEAMINOPYRIMIDINES | Boehringer Ingelheim International GmbH (DE) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007146977-A1 | 2-ANILINO-4-AMINOALKYLENEAMINOPYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-12-21 | — | — | WO | disclosed |