Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 9/20 | 0.66 |
| ▸ | CNR1 | P21554 | 6/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4195914 | 0.87 | CNR1 (0.69) | CNR2CNR1NPC1CYP2C9CYP1A2 | |
| SCHEMBL4204619 | 0.87 | CNR2 (0.66) | CNR2CNR1NPC1CYP3A4CYP2C9 | |
| SCHEMBL27684178 | 0.81 | CNR1 (0.72) | CNR2CNR1NPC1POLBTSHR | |
| SCHEMBL4190614 | 0.81 | CNR2 (0.61) | CNR2CNR1NPC1CYP3A4CYP2C9 | |
| SCHEMBL4193009 | 0.81 | CNR2 (0.69) | CNR2CNR1NPC1CYP3A4CYP2C9 | |
| SCHEMBL4198495 | 0.79 | CNR1 (0.75) | CNR2CNR1NPC1POLBTSHR | |
| SCHEMBL4193303 | 0.79 | CNR1 (0.75) | CNR2CNR1 | |
| SCHEMBL4188684 | 0.79 | CNR1 (0.72) | CNR2CNR1NPC1POLBTSHR | |
| SCHEMBL4188696 | 0.79 | CNR2 (0.63) | CNR2CNR1NPC1POLBTSHR | |
| SCHEMBL4190780 | 0.79 | CNR1 (1.00) | CNR2CNR1NPC1CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | claimed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | claimed |
| EP-1756044-A1 | THERAPEUTIC COMPOUNDS | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005115972-A1 | THERAPEUTIC COMPOUNDS | ASTRAZENECA AB (SE) | 2005-12-08 | — | — | WO | disclosed |