Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2419820 | 0.92 | MEN1 (0.48) | MEN1KMT2AMAPTLMNAKDM4E | |
| SCHEMBL2419239 | 0.91 | MAPT (0.48) | MEN1KMT2AMAPTCA2CA1 | |
| SCHEMBL2422685 | 0.91 | KMT2A (0.49) | MEN1KMT2AMAPTGAALMNA | |
| SCHEMBL2423977 | 0.86 | KMT2A (0.48) | MEN1KMT2AMAPTLMNAKDM4E | |
| SCHEMBL2423188 | 0.85 | KMT2A (0.48) | MEN1KMT2AMAPTLMNAMAPK9 | |
| SCHEMBL2421018 | 0.85 | ALDH1A1 (0.47) | MEN1KMT2AMAPTCA2CA1 | |
| SCHEMBL2425308 | 0.85 | MEN1 (0.45) | MEN1KMT2AMAPTLMNAKDM4E | |
| SCHEMBL2427809 | 0.84 | KMT2A (0.50) | MEN1KMT2AMAPTGAAMAPK9 | |
| SCHEMBL3480013 | 0.83 | MAPT (0.50) | MEN1KMT2AMAPTGAALMNA | |
| SCHEMBL2426328 | 0.83 | MAPT (0.46) | MEN1KMT2AMAPTGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2026802-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | Laboratoires Serono SA (CH) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007141224-A2 | JNK INHIBITORS FOR TREATMENT OF SKIN DISEASES | LABORATOIRES SERONO SA (CH) | 2007-12-13 | — | — | WO | disclosed |