Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 10/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.49 |
| ▸ | CFTR | P13569 | 1/20 | 0.47 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3282271 | 0.83 | POLB (0.43) | KCNA5KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7428103 | 0.78 | POLB (0.48) | KCNA5KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL884965 | 0.78 | CYP1A2 (0.56) | KCNA5KCNH2SLC6A2SLC6A4SLC6A3 | |
| Ammonia Solution, Strong SCHEMBL5999435 | 0.77 | POLB (0.50) | KCNA5KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9159585 | 0.76 | CYP19A1 (0.63) | KCNA5KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL884939 | 0.76 | KCNA5 (0.64) | KCNA5KCNH2 | |
| SCHEMBL2063360 | 0.76 | KCNA5 (0.71) | KCNA5KCNH2 | |
| SCHEMBL2063347 | 0.76 | KCNA5 (0.62) | KCNA5KCNH2 | |
| SCHEMBL884692 | 0.76 | KCNH2 (0.50) | KCNA5KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7289084 | 0.76 | HRH1 (0.52) | KCNA5KCNH2SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781635-A4 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2009-02-25 | — | — | EP | claimed |
| EP-1781635-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2007-05-09 | — | — | EP | claimed |
| WO-2006015159-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2006-02-09 | — | — | WO | claimed |
| EP-1781635-A4 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2009-02-25 | — | — | EP | disclosed |
| EP-1781635-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006015159-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2006-02-09 | — | — | WO | disclosed |