Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | CFTR | P13569 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8827578 | 0.88 | CFTR (0.59) | EPHX2CFTRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7878877 | 0.88 | CFTR (0.57) | CFTRSLC6A2SLC6A4SLC6A3GOPC | |
| Ammonia Solution, Strong SCHEMBL5999435 | 0.82 | POLB (0.50) | POLBEPHX2CFTRSLC6A2SLC6A4 | |
| SCHEMBL7430169 | 0.82 | CYP19A1 (0.44) | POLBSLC6A4SMN1; SMN2LMNAHTT | |
| SCHEMBL7289084 | 0.81 | HRH1 (0.52) | POLBEPHX2CFTRSLC6A2SLC6A4 | |
| SCHEMBL1283383 | 0.80 | IDO1 (0.41) | LMNACYP19A1 | |
| SCHEMBL4197953 | 0.78 | KCNA5 (0.50) | POLBCFTRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7810718 | 0.77 | TBXAS1 (0.53) | POLBEPHX2CFTRSLC6A2SLC6A4 | |
| SCHEMBL9030394 | 0.77 | TBXAS1 (0.57) | POLBEPHX2CFTRSLC6A2SLC6A4 | |
| SCHEMBL1378412 | 0.77 | KCNA5 (0.56) | POLBEPHX2CFTRSLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0448765-B1 | Use of guanidine derivatives for the manufacture of a medicament with NPY-antagonistic activity | HEUMANN PHARMA GMBH & CO (DE) | 1994-08-17 | — | — | EP | claimed |
| WO-1992022295-A1 | USE OF GUANIDINE DERIVATIVES IN THE PREPARATION OF A DRUG FOR THE TREATMENT OF SEPSIS AND SEPSIS-LIKE CONDITIONS AND SEPTIC SHOCK | NEUGEBAUER EDMUND (DE) | 1992-12-23 | — | — | WO | claimed |
| EP-0448765-A1 | Use of guanidine derivatives for the manufacture of a medicament with NPY-antagonistic activity | HEUMANN PHARMA GMBH & CO (DE) | 1991-10-02 | — | — | EP | claimed |
| EP-0448765-B1 | Use of guanidine derivatives for the manufacture of a medicament with NPY-antagonistic activity | HEUMANN PHARMA GMBH & CO (DE) | 1994-08-17 | — | — | EP | disclosed |
| WO-1992022295-A1 | USE OF GUANIDINE DERIVATIVES IN THE PREPARATION OF A DRUG FOR THE TREATMENT OF SEPSIS AND SEPSIS-LIKE CONDITIONS AND SEPTIC SHOCK | NEUGEBAUER EDMUND (DE) | 1992-12-23 | — | — | WO | disclosed |
| EP-0448765-A1 | Use of guanidine derivatives for the manufacture of a medicament with NPY-antagonistic activity | HEUMANN PHARMA GMBH & CO (DE) | 1991-10-02 | — | — | EP | disclosed |