Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2460282 | 0.80 | JAK2 (0.58) | JAK2KCNH2CHEK1 | |
| SCHEMBL2458380 | 0.72 | JAK2 (1.00) | JAK2KCNH2 | |
| SCHEMBL2458860 | 0.70 | JAK2 (0.72) | JAK2KCNH2 | |
| SCHEMBL2455686 | 0.69 | JAK2 (0.65) | JAK2KCNH2 | |
| SCHEMBL12333319 | 0.63 | JAK2 (0.62) | JAK2KCNH2CHEK1 | |
| SCHEMBL12333441 | 0.63 | JAK2 (0.62) | JAK2KCNH2CHEK1 | |
| SCHEMBL2358966 | 0.63 | JAK2 (0.54) | JAK2KCNH2CHEK1 | |
| SCHEMBL2458089 | 0.63 | JAK2 (0.68) | JAK2KCNH2CHEK1 | |
| SCHEMBL2459085 | 0.62 | JAK2 (0.55) | JAK2KCNH2CHEK1 | |
| SCHEMBL2460612 | 0.62 | JAK2 (0.76) | JAK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134346-A1 | INHIBITORS OF JANUS KINASES AND/OR 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE-1 | Merck & Co., Inc. (US) | 2009-12-23 | — | — | EP | claimed |
| WO-2008112217-A1 | INHIBITORS OF JANUS KINASES AND/OR 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE-1 | MERCK & CO., INC. (US) | 2008-09-18 | — | — | WO | claimed |