Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.53 |
| ▸ | FAAH | O00519 | 15/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1011137 | 0.95 | CYP3A4 (0.57) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1011604 | 0.87 | CYP3A4 (0.49) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1011585 | 0.86 | CYP3A4 (0.72) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1037319 | 0.81 | CYP2D6 (0.47) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1036377 | 0.79 | CYP2D6 (0.44) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1009330 | 0.78 | CYP3A4 (0.57) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| Hydrochloric Acid SCHEMBL4184397 | 0.78 | FAAH (0.47) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1011746 | 0.77 | CYP3A4 (0.84) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1034832 | 0.77 | CYP3A4 (0.46) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1036375 | 0.77 | CYP3A4 (0.44) | CYP3A4CYP2D6FAAHGABRA1ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076508-A2 | BIARYL ETHER UREA COMPOUNDS | Pfizer Products Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008047229-A2 | BIARYL ETHER UREA COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2008-04-24 | — | — | WO | disclosed |