Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 17/20 | 0.50 |
| ▸ | CCND1 | P24385 | 10/20 | 0.50 |
| ▸ | CCND2 | P30279 | 9/20 | 0.50 |
| ▸ | CCND3 | P30281 | 9/20 | 0.50 |
| ▸ | AURKA | O14965 | 7/20 | 0.47 |
| ▸ | CDK1 | P06493 | 3/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.47 |
| ▸ | CDK2 | P24941 | 5/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4200615 | 0.84 | CDK4 (0.49) | CDK4CCND1CCND2CCND3AURKA | |
| SCHEMBL7713198 | 0.83 | CDK4 (0.62) | CDK4CCND1CCND2CCND3AURKA | |
| SCHEMBL4195694 | 0.83 | CDK4 (0.50) | CDK4CCND1CCND2CCND3AURKA | |
| SCHEMBL4200620 | 0.82 | CDK4 (0.51) | CDK4CCND1CCND2CCND3AURKA | |
| SCHEMBL4342366 | 0.82 | CDK4 (0.60) | CDK4CCND1CCND2CCND3CDK1 | |
| SCHEMBL7706847 | 0.80 | ALK (0.58) | CDK4CCND1CDK2CCNE1 | |
| SCHEMBL11977054 | 0.80 | SYK (0.55) | CDK4CCND1CCND2CCND3AURKA | |
| SCHEMBL4515832 | 0.76 | CCND3 (0.57) | CDK4CCND1CCND2CCND3CDK2 | |
| SCHEMBL11976956 | 0.73 | JAK2 (0.57) | — | |
| SCHEMBL11977047 | 0.73 | CDK4 (0.62) | CDK4CCND1CCND2CCND3CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029145-A2 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | Novartis Ag (CH) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007140222-A2 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2007-12-06 | — | — | WO | disclosed |