Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 9/20 | 0.51 |
| ▸ | CCND1 | P24385 | 5/20 | 0.51 |
| ▸ | CCND2 | P30279 | 5/20 | 0.51 |
| ▸ | CCND3 | P30281 | 5/20 | 0.51 |
| ▸ | STAT6 | P42226 | 7/20 | 0.49 |
| ▸ | AURKA | O14965 | 4/20 | 0.48 |
| ▸ | INSR | P06213 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | CDK7 | P50613 | 1/20 | 0.48 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.48 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.47 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4189970 | 0.82 | STAT6 (0.65) | CDK4CCND1CCND2CCND3STAT6 | |
| SCHEMBL4200618 | 0.82 | CDK4 (0.50) | CDK4CCND1CCND2CCND3AURKA | |
| SCHEMBL4192080 | 0.77 | CCND3 (0.55) | CDK4CCND1CCND2CCND3STAT6 | |
| SCHEMBL15163242 | 0.75 | STAT6 (0.67) | CDK4CCND1CCND2CCND3STAT6 | |
| SCHEMBL3790571 | 0.73 | STAT6 (0.68) | CDK4CCND1CCND2CCND3STAT6 | |
| SCHEMBL4202387 | 0.73 | STAT6 (0.53) | CDK4CCND1CCND2CCND3STAT6 | |
| SCHEMBL1284279 | 0.72 | TBK1 (0.70) | CDK4CCND1CCND2CCND3STAT6 | |
| SCHEMBL27844369 | 0.72 | STAT6 (0.69) | CDK4CCND1CCND2CCND3STAT6 | |
| SCHEMBL30019212 | 0.72 | STAT6 (0.62) | CDK4CCND1CCND2CCND3STAT6 | |
| SCHEMBL4191373 | 0.71 | CCND3 (0.47) | CDK4CCND1CCND2CCND3CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029145-A2 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | Novartis Ag (CH) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007140222-A2 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2007-12-06 | — | — | WO | disclosed |