Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.69 |
| ▸ | MAPT | P10636 | 5/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.69 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | NPC1 | O15118 | 6/20 | 0.62 |
| ▸ | RAB9A | P51151 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | GCK | P35557 | 1/20 | 0.60 |
| ▸ | GRM5 | P41594 | 1/20 | 0.60 |
| ▸ | LCK | P06239 | 2/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3581515 | 0.87 | RAB9A (0.81) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL3582729 | 0.85 | NPC1 (0.73) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL3581996 | 0.85 | KDM4E (0.67) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL3580760 | 0.84 | SCD (0.65) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL4346190 | 0.84 | NPC1 (0.80) | MEN1KMT2AALDH1A1KDM4ENPC1 | |
| SCHEMBL3591591 | 0.84 | NPC1 (0.64) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL4188640 | 0.84 | NPC1 (0.60) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL27727775 | 0.82 | MEN1 (0.51) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL3583698 | 0.82 | KMT2A (1.00) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL4193912 | 0.82 | RAB9A (0.59) | MEN1KMT2AMAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029138-A1 | AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007130075-A1 | AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2007-11-15 | — | — | WO | disclosed |