Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 19/20 | 0.79 |
| ▸ | HTR3A | P46098 | 8/20 | 0.79 |
| ▸ | HTR3E | A5X5Y0 | 7/20 | 0.79 |
| ▸ | HTR3B | O95264 | 7/20 | 0.79 |
| ▸ | HTR3D | Q70Z44 | 7/20 | 0.79 |
| ▸ | HTR3C | Q8WXA8 | 7/20 | 0.79 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.54 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.54 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.54 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4207143 | 1.00 | CHRNA7 (0.79) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL4201891 | 1.00 | CHRNA7 (0.79) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL4195124 | 0.88 | CHRNA7 (1.00) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL372893 | 0.88 | CHRNA7 (1.00) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL4194893 | 0.88 | CHRNA7 (1.00) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL6806889 | 0.88 | CHRNA7 (1.00) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL4200197 | 0.88 | CHRNA7 (0.78) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL4194858 | 0.88 | CHRNA7 (0.78) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL4207665 | 0.88 | CHRNA7 (0.78) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| Hydrochloric Acid SCHEMBL7061150 | 0.87 | CHRNA7 (0.98) | CHRNA7HTR3AHTR3EHTR3BHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545537-B9 | ALPHA-7 NICOTINIC RECEPTOR AGONISTS AND STATINS IN COMBINATION | ASTRAZENECA AB (SE) | 2008-08-20 | — | — | EP | claimed |
| US-7214688-B2 | Compounds | ASTRAZENECA AB (SE) | 2007-05-08 | — | — | US | claimed |
| EP-1545537-B1 | ALPHA-7 NICOTINIC RECEPTOR AGONISTS AND STATINS IN COMBINATION | ASTRAZENECA AB (SE) | 2007-04-04 | — | — | EP | claimed |
| US-20060128749-A1 | Compounds | PHILLIPS EIFION | 2006-06-15 | — | — | US | claimed |
| US-20050256146-A1 | Alpha-7 nicotinic receptor agonists and stains in combination | ASTRAZENECA AB (SE) | 2005-11-17 | — | — | US | claimed |
| EP-1545537-A1 | ALPHA-7 NICOTINIC RECEPTOR AGONISTS AND STATINS IN COMBINATION | AstraZeneca AB (SE) | 2005-06-29 | — | — | EP | claimed |
| US-20040259909-A1 | Treatment of fibromyalgia syndrome | ASTRAZENECA AB (SE) | 2004-12-23 | — | — | US | claimed |
| WO-2004019947-A1 | ALPHA-7 NICOTINIC RECEPTOR AGONISTS AND STATINS IN COMBINATION | ASTRAZENECA AB (SE) | 2004-03-11 | — | — | WO | claimed |
| EP-1259508-B1 | NOVEL BIARYLCARBOXAMIDES | ASTRAZENECA AB (SE) | 2003-10-15 | — | — | EP | claimed |
| US-20030008867-A1 | Compounds | ASTRAZENECA AB (SE) | 2003-01-09 | — | — | US | claimed |
| EP-1259508-A1 | NOVEL BIARYLCARBOXAMIDES | AstraZeneca AB (SE) | 2002-11-27 | — | — | EP | claimed |
| WO-2001060821-A1 | NOVEL BIARYLCARBOXAMIDES | ASTRAZENECA AB (SE) | 2001-08-23 | — | — | WO | claimed |
| US-20090192180-A1 | Alpha-7 Nicotinic Receptor Agonists and Statins In Combination | KEITH RICHARD | 2009-07-30 | — | — | US | disclosed |
| US-7491734-B2 | 2-(pyridine-4-yl)-N-(quinuclidin-2-yl)thiazole-4-carboxide nicotinic acetylcholine receptor ligands | ASTRAZENECA AB (SE) | 2009-02-17 | — | — | US | disclosed |
| EP-1545537-B9 | ALPHA-7 NICOTINIC RECEPTOR AGONISTS AND STATINS IN COMBINATION | ASTRAZENECA AB (SE) | 2008-08-20 | — | — | EP | disclosed |
| US-20070149563-A1 | New Compounds | PHILLIPS EIFION | 2007-06-28 | — | — | US | disclosed |
| US-20040259909-A1 | Treatment of fibromyalgia syndrome | ASTRAZENECA AB (SE) | 2004-12-23 | — | — | US | disclosed |
| WO-2004019947-A1 | ALPHA-7 NICOTINIC RECEPTOR AGONISTS AND STATINS IN COMBINATION | ASTRAZENECA AB (SE) | 2004-03-11 | — | — | WO | disclosed |
| EP-1259508-B1 | NOVEL BIARYLCARBOXAMIDES | ASTRAZENECA AB (SE) | 2003-10-15 | — | — | EP | disclosed |
| US-20030008867-A1 | Compounds | ASTRAZENECA AB (SE) | 2003-01-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128749-A1 | Compounds | DRD2, DRD1, GRIN2A | CHRNA7 302/4885HTR3A 737/4885HTR3E 601/4885 |
| US-20070149563-A1 | New Compounds | DRD1, DRD2, GRIN2A | CHRNA7 145/4885HTR3A 667/4885HTR3E 569/4885 |
| US-20030008867-A1 | Compounds | DRD2, DRD1, GRIN2A | CHRNA7 209/4885HTR3A 347/4885HTR3E 350/4885 |
| US-20040259909-A1 | Treatment of fibromyalgia syndrome | CHRNA7, CHRNA5, CHRNA10 | CHRNA7 1/4885HTR3A 71/4885HTR3E 251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.