Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 3/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8546618 | 0.93 | HSD17B10 (0.39) | TSHRHSD17B10HDAC3HDAC1HDAC2 | |
| SCHEMBL1845681 | 0.84 | HTT (0.41) | TSHRHSD17B10HDAC3HDAC1HDAC2 | |
| SCHEMBL1845437 | 0.84 | TSHR (0.55) | TSHRHSD17B10HTTCA12CA14 | |
| SCHEMBL5014070 | 0.80 | HDAC1 (0.43) | TSHRHSD17B10HDAC3HDAC1HDAC2 | |
| SCHEMBL8546872 | 0.79 | MAPT (0.41) | TSHRHSD17B10HDAC3HDAC1HDAC2 | |
| SCHEMBL23768567 | 0.79 | CYP2C9 (0.40) | HSD17B10HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL882496 | 0.79 | TDP1 (0.39) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL13062086 | 0.78 | HDAC3 (0.37) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL2904495 | 0.78 | TSHR (0.65) | TSHRHSD17B10HTTCA12CA14 | |
| SCHEMBL9218327 | 0.77 | HDAC3 (0.35) | HDAC3HDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482376-B2 | Conjugated complement cascade inhibitors | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2009-01-27 | — | — | US | disclosed |
| US-7482376-B2 | Conjugated complement cascade inhibitors | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2009-01-27 | — | — | US | disclosed |
| US-7482376-B2 | Conjugated complement cascade inhibitors | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2009-01-27 | — | — | US | disclosed |
| EP-1644046-A2 | CONJUGATED COMPLEMENT CASCADE INHIBITORS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005002627-A2 | CONJUGATED COMPLEMENT CASCADE INHIBITORS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2005-01-13 | — | — | WO | disclosed |
| US-20050004031-A1 | Conjugated complement cascade inhibitors | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004031-A1 | Conjugated complement cascade inhibitors | C9, CFH, CFB | TSHR 2818/4885HSD17B10 2254/4885HDAC3 3430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.