Cyclopropane

SCHEMBL4204875

C1CC1.CN(C)C(=O)CC(c1ccc(OC(F)F)c(OC(F)F)c1)N1Cc2cccc(NC(=O)O)c2C1=O

nearest known ligand 0.42

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	MEN1	O00255	2/20	0.39

▸	KMT2A	Q03164	2/20	0.39

▸	MAPT	P10636	6/20	0.38

▸	TP53	P04637	5/20	0.38

▸	POLB	P06746	1/20	0.35

▸	TDP1	Q9NUW8	1/20	0.35

▸	PDE4A	P27815	1/20	0.35

▸	PDE4B	Q07343	1/20	0.35

▸	PDE4C	Q08493	1/20	0.35

▸	PDE4D	Q08499	1/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Cyclopropane SCHEMBL4206835	0.89	PDE4A (0.41)	MEN1KMT2AMAPTTP53POLB
SCHEMBL1143748	0.89	MAPT (0.37)	MEN1KMT2AMAPTTP53PDE4A
Cyclopropane SCHEMBL4211055	0.89	MEN1 (0.41)	MEN1KMT2AMAPTTP53POLB
SCHEMBL1143358	0.87	PDE4B (0.49)	MEN1KMT2AMAPTTP53PDE4A
Cyclopropane SCHEMBL4200950	0.87	PDE4B (0.51)	MEN1KMT2ATP53PDE4APDE4B
Cyclopropane SCHEMBL4206831	0.86	TP53 (0.46)	MEN1KMT2AMAPTTP53TDP1
SCHEMBL1143603	0.85	TP53 (0.41)	MEN1KMT2AMAPTTP53POLB
Cyclopropane SCHEMBL4206531	0.83	PDE4B (0.51)	PDE4APDE4BPDE4CPDE4D
SCHEMBL1143574	0.81	PDE4A (0.51)	MEN1KMT2AMAPTTP53PDE4A
SCHEMBL1143956	0.80	MEN1 (0.39)	MEN1KMT2AMAPTTP53PDE4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1587474-B1	FLUOROALKOXY-SUBSTITUTED 1, 3-DIHYDRO-ISOINDOLYL COMPOUNDS AND THEIR PHARMACEUTICAL USES	CELGENE CORP (US)	2009-11-18	—	—	EP	claimed