Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclopropane SCHEMBL4206831 | 0.94 | TP53 (0.46) | MEN1KMT2AMAPTTDP1TP53 | |
| Cyclopropane SCHEMBL4206835 | 0.91 | PDE4A (0.41) | MEN1KMT2AMAPTTDP1TP53 | |
| Cyclopropane SCHEMBL4204875 | 0.89 | MEN1 (0.39) | MEN1KMT2AMAPTTDP1TP53 | |
| SCHEMBL1144306 | 0.89 | MAPT (0.40) | MEN1KMT2AMAPTTDP1TP53 | |
| SCHEMBL1143447 | 0.85 | PDE4A (0.49) | MEN1KMT2AMAPTTP53 | |
| Cyclopropane SCHEMBL4200950 | 0.85 | PDE4B (0.51) | MEN1KMT2ATP53 | |
| Cyclopropane SCHEMBL15252535 | 0.85 | TP53 (0.52) | MEN1KMT2AMAPTTP53 | |
| SCHEMBL1143737 | 0.83 | TP53 (0.44) | MEN1KMT2AMAPTTP53 | |
| SCHEMBL1143956 | 0.82 | MEN1 (0.39) | MEN1KMT2AMAPTTP53 | |
| Cyclopropane SCHEMBL4206531 | 0.81 | PDE4B (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1587474-B1 | FLUOROALKOXY-SUBSTITUTED 1, 3-DIHYDRO-ISOINDOLYL COMPOUNDS AND THEIR PHARMACEUTICAL USES | CELGENE CORP (US) | 2009-11-18 | — | — | EP | claimed |