Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lomefloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 1.00 |
| ▸ | HPGD | P15428 | 5/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.61 |
| ▸ | CLK2 | P49760 | 1/20 | 0.61 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lomefloxacin SCHEMBL27842937 | 1.00 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDPMP22 | |
| Lomefloxacin SCHEMBL30034879 | 1.00 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDPMP22 | |
| Lomefloxacin SCHEMBL2636428 | 1.00 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDPMP22 | |
| Lomefloxacin SCHEMBL28121708 | 1.00 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDPMP22 | |
| Lomefloxacin SCHEMBL42051 | 1.00 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDPMP22 | |
| Lomefloxacin SCHEMBL8912235 | 1.00 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDPMP22 | |
| Lomefloxacin SCHEMBL29895425 | 0.99 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDPMP22 | |
| Lomefloxacin SCHEMBL34609 | 0.99 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDPMP22 | |
| Lomefloxacin SCHEMBL29388501 | 0.99 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDPMP22 | |
| Lomefloxacin SCHEMBL34610 | 0.99 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2569 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118978426-B | Acidizing method of glycerin, acidized glycerin and application thereof | 浙江大学 | 2025-05-16 | — | — | CN | claimed |
| CN-119896636-A | Lomefloxacin hydrochloride ear drop composition, product, preparation method and application thereof | 浙江大学 | 2025-04-29 | — | — | CN | claimed |
| US-12274830-B2 | Nitric oxide inhalation therapy for infants with bronchiolitis | BEYOND AIR LTD (IL) | 2025-04-15 | — | — | US | claimed |
| CN-119793433-A | C (C)60CNT composite photocatalytic material and preparation method and application thereof | 湖北大学 | 2025-04-11 | — | — | CN | claimed |
| CN-118978426-A | Acidizing method of glycerin, acidized glycerin and application thereof | 浙江大学 | 2024-11-19 | — | — | CN | claimed |
| CN-118496455-A | Fluorinated triazine covalent organic framework material and preparation method and application thereof | 武汉工程大学 | 2024-08-16 | — | — | CN | claimed |
| CN-118191116-A | Method for detecting illegally added medicines in eucommia ulmoides leaf extract | 山东省饲料兽药质量检验中心 | 2024-06-14 | — | — | CN | claimed |
| CN-118121709-A | Ophthalmic pharmaceutical composition, and preparation method and application thereof | 山东序列生物科技有限公司 | 2024-06-04 | — | — | CN | claimed |
| US-20240173512-A1 | METHODS FOR POTENTIATING ANTIMICROBIAL AGENTS | STREETERVILLE CAPITAL, LLC | 2024-05-30 | — | — | US | claimed |
| CN-117624046-A | Synthesis method of ethoxylomefloxacin | 江苏吉贝尔药业股份有限公司 | 2024-03-01 | — | — | CN | claimed |
| EP-1180020-A2 | POROUS DRUG MATRICES AND METHODS OF MANUFACTURE THEREOF | Acusphere, Inc. (US) | 2002-02-20 | — | — | EP | claimed |
| WO-2000072827-A9 | POROUS DRUG MATRICES AND METHODS OF MANUFACTURE THEREOF | ACUSPHERE INC (US) | 2002-01-31 | — | — | WO | claimed |
| US-6172069-B1 | CONTROLLING TIME OF ADMINISTERING | G. D. SEARLE & COMPANY | 2001-01-09 | — | — | US | claimed |
| US-6162447-A | Microstructured compositions | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2000-12-19 | — | — | US | claimed |
| WO-2000072827-A2 | POROUS DRUG MATRICES AND METHODS OF MANUFACTURE THEREOF | ACUSPHERE, INC. (US) | 2000-12-07 | — | — | WO | claimed |
| EP-0875244-A2 | Cosmetically accceptable microstructured compositions | Ciba SC Holding AG (CH) | 1998-11-04 | — | — | EP | claimed |
| US-5811547-A | Method for inducing crystalline state transition in medicinal substance | NIPPON SHINYAJU CO., LTD. (JP) | 1998-09-22 | — | — | US | claimed |
| US-5668134-A | LOMEFLOXACIN HYDROCHLORIDE | G. D. SEARLE & CO. (US) | 1997-09-16 | — | — | US | claimed |
| EP-0741570-A1 | METHOD FOR PREVENTING OR REDUCING PHOTOSENSITIVITY AND/OR PHOTOTOXICITY REACTIONS TO MEDICATIONS | G.D. SEARLE & CO. (US) | 1996-11-13 | — | — | EP | claimed |
| WO-1995020387-A1 | METHOD FOR PREVENTING OR REDUCING PHOTOSENSITIVITY AND/OR PHOTOTOXICITY REACTIONS TO MEDICATIONS | G.D. SEARLE & CO. (US) | 1995-08-03 | — | — | WO | claimed |