Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lomefloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 1.00 |
| ▸ | HPGD | P15428 | 5/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.62 |
| ▸ | CLK2 | P49760 | 1/20 | 0.62 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lomefloxacin SCHEMBL34610 | 1.00 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDPMP22 | |
| Lomefloxacin SCHEMBL29895425 | 1.00 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDPMP22 | |
| Lomefloxacin SCHEMBL9226104 | 1.00 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDPMP22 | |
| Lomefloxacin SCHEMBL29388501 | 1.00 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDPMP22 | |
| Lomefloxacin SCHEMBL133835 | 1.00 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDPMP22 | |
| Lomefloxacin SCHEMBL8912235 | 0.99 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDPMP22 | |
| Lomefloxacin SCHEMBL30034879 | 0.99 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDPMP22 | |
| Lomefloxacin SCHEMBL42051 | 0.99 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDPMP22 | |
| Lomefloxacin SCHEMBL42052 | 0.99 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDPMP22 | |
| Lomefloxacin SCHEMBL2636428 | 0.99 | KDM4E (1.00) | KDM4EHSD17B10ALDH1A1HPGDPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 24067 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12624057-B2 | Bisphosphonate quinolone conjugates and uses thereof | BIOVINC, LLC (US) | 2026-05-12 | — | — | US | claimed |
| US-20260108619-A1 | CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2026-04-23 | — | — | US | claimed |
| EP-4434588-B1 | AEROSOL DELIVERY DEVICE | PARI PHARMA GMBH (DE) | 2026-04-08 | — | — | EP | claimed |
| US-12576124-B2 | Formulation of a conjugate of a tubulysin analog to a cell-binding molecule | HANGZHOU DAC BIOTECH CO., LTD (CN) | 2026-03-17 | — | — | US | claimed |
| EP-4694929-A1 | METHODS FOR TREATING CORNEAL INJURIES | Lin, Sung-Jan (TW) | 2026-02-18 | — | — | EP | claimed |
| US-20260027140-A1 | COMPOSITIONS AND METHODS FOR TREATING AND AMELIORATING RESPIRATORY CONDITIONS AND INFLAMMATION OF MUCOSA | ATOPIC MEDICAL INC (US) | 2026-01-29 | — | — | US | claimed |
| EP-4659014-A1 | EMULSION-BASED THICK-FILM ANTIFOULING COATING FOR HIGHLY SENSITIVE ELECTROCHEMICAL SENSING | President And Fellows Of Harvard College (US) | 2025-12-10 | — | — | EP | claimed |
| US-12465623-B2 | Use of parasites and extracellular vesicles obtained from parasites in cancer treatment | YEDITEPE UNIVERSITESI (TR) | 2025-11-11 | — | — | US | claimed |
| US-20250339551-A1 | AN ANTIBODY-DRUG CONJUGATE HAVING TWO OR MORE DIFFERENT FUNCTIONAL SMALL MOLECULES FOR ENHANCED TREATMENT OF REFRACTORY DISEASES | HANGZHOU SEEHE BIOTECHNOLOGY CO., LTD (CN) | 2025-11-06 | — | — | US | claimed |
| EP-4642484-A1 | TARGETED TREATMENT OF PROSTATE CANCERS AND OTHER TUMORS BY AN ANTIBODY-DRUG CONJUGATE | Hangzhou Seehe Biotechnology Co., Ltd (CN) | 2025-11-05 | — | — | EP | claimed |
| EP-0322892-B1 | FREEZE-DRIED PHARMACEUTICAL PREPARATIONS FOR PARENTERAL USE | KYORIN SEIYAKU KABUSHIKI KAISHA (JP) | 1992-03-25 | — | — | EP | claimed |
| EP-0470252-A1 | ANTI-HIV DRUG | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1992-02-12 | — | — | EP | claimed |
| EP-0443381-A1 | Effervescent composition, its production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-08-28 | — | — | EP | claimed |
| WO-1991009616-A1 | QUINOLONE ANTIBIOTICS ENCAPSULATED IN LIPID VESICLES | YALE UNIVERSITY (US) | 1991-07-11 | — | — | WO | claimed |
| EP-0394553-A2 | Use of fluorine containing pyridone carboxylic acid derivatives for preparing a medicament for the treatment of HIV infections | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1990-10-31 | — | — | EP | claimed |
| EP-0322892-A1 | Freeze-dried pharmaceutical preparations for parenteral use | KYORIN SEIYAKU KABUSHIKI KAISHA (JP) | 1989-07-05 | — | — | EP | claimed |
| US-4780465-A | ISOTONIZED WITH POLYALCOHOL OR BORIC ACID; MICROBIOCIDE | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1988-10-25 | — | — | US | claimed |
| EP-0140116-B1 | A 6-FLUORO-1,4-DIHYDRO-4-OXO-7-SUBSTITUTED PIPERAZINYL-QUINOLINE-3-CARBOXYLIC ACID DERIVATIVE AND THE METHOD FOR PREPARING THE SAME | Hokuriku Pharmaceutical Co.,Ltd (JP) | 1988-05-25 | — | — | EP | claimed |
| US-4528287-A | 6-Fluoro-1, 4-dihydro-4-oxo-7-substituted piperazinylquinoline-3-carboxylic acids and the method for preparing the same | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1985-07-09 | — | — | US | claimed |
| EP-0140116-A1 | A 6-fluoro-1,4-dihydro-4-oxo-7-substituted piperazinyl-quinoline-3-carboxylic acid derivative and the method for preparing the same | Hokuriku Pharmaceutical Co.,Ltd (JP) | 1985-05-08 | — | — | EP | claimed |