Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 15/20 | 0.71 |
| ▸ | HTR3E | A5X5Y0 | 8/20 | 0.71 |
| ▸ | HTR3B | O95264 | 8/20 | 0.71 |
| ▸ | HTR3A | P46098 | 8/20 | 0.71 |
| ▸ | HTR3D | Q70Z44 | 8/20 | 0.71 |
| ▸ | HTR3C | Q8WXA8 | 8/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.59 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4205298 | 1.00 | CHRNA7 (0.71) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4198180 | 0.90 | CHRNA7 (0.60) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4198182 | 0.90 | CHRNA7 (0.60) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4196152 | 0.89 | CHRNA7 (0.61) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4205130 | 0.89 | CHRNA7 (0.61) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4206206 | 0.89 | CHRNA7 (0.70) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4206208 | 0.89 | CHRNA7 (0.70) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4201779 | 0.89 | CHRNA7 (0.60) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4201780 | 0.89 | CHRNA7 (0.60) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL3499803 | 0.88 | CHRNA7 (0.74) | CHRNA7HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545537-B9 | ALPHA-7 NICOTINIC RECEPTOR AGONISTS AND STATINS IN COMBINATION | ASTRAZENECA AB (SE) | 2008-08-20 | — | — | EP | claimed |
| EP-1545537-B1 | ALPHA-7 NICOTINIC RECEPTOR AGONISTS AND STATINS IN COMBINATION | ASTRAZENECA AB (SE) | 2007-04-04 | — | — | EP | claimed |
| US-20050256146-A1 | Alpha-7 nicotinic receptor agonists and stains in combination | ASTRAZENECA AB (SE) | 2005-11-17 | — | — | US | claimed |
| EP-1545537-A1 | ALPHA-7 NICOTINIC RECEPTOR AGONISTS AND STATINS IN COMBINATION | AstraZeneca AB (SE) | 2005-06-29 | — | — | EP | claimed |
| US-20040259909-A1 | Treatment of fibromyalgia syndrome | ASTRAZENECA AB (SE) | 2004-12-23 | — | — | US | claimed |
| WO-2004019947-A1 | ALPHA-7 NICOTINIC RECEPTOR AGONISTS AND STATINS IN COMBINATION | ASTRAZENECA AB (SE) | 2004-03-11 | — | — | WO | claimed |
| EP-1259508-B1 | NOVEL BIARYLCARBOXAMIDES | ASTRAZENECA AB (SE) | 2003-10-15 | — | — | EP | claimed |
| US-20030008867-A1 | Compounds | ASTRAZENECA AB (SE) | 2003-01-09 | — | — | US | claimed |
| EP-1259508-A1 | NOVEL BIARYLCARBOXAMIDES | AstraZeneca AB (SE) | 2002-11-27 | — | — | EP | claimed |
| WO-2001060821-A1 | NOVEL BIARYLCARBOXAMIDES | ASTRAZENECA AB (SE) | 2001-08-23 | — | — | WO | claimed |
| EP-4559918-A2 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | Genzyme Corporation (US) | 2025-05-28 | — | — | EP | disclosed |
| EP-3673906-B1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GENZYME CORP (US) | 2025-05-14 | — | — | EP | disclosed |
| US-20090192180-A1 | Alpha-7 Nicotinic Receptor Agonists and Statins In Combination | KEITH RICHARD | 2009-07-30 | — | — | US | disclosed |
| US-7491734-B2 | 2-(pyridine-4-yl)-N-(quinuclidin-2-yl)thiazole-4-carboxide nicotinic acetylcholine receptor ligands | ASTRAZENECA AB (SE) | 2009-02-17 | — | — | US | disclosed |
| EP-1545537-B9 | ALPHA-7 NICOTINIC RECEPTOR AGONISTS AND STATINS IN COMBINATION | ASTRAZENECA AB (SE) | 2008-08-20 | — | — | EP | disclosed |
| EP-1259508-B1 | NOVEL BIARYLCARBOXAMIDES | ASTRAZENECA AB (SE) | 2003-10-15 | — | — | EP | disclosed |
| WO-2003032897-A2 | AZABICYCLIC COMPOUNDS FOR THE TREATMENT OF FIBROMYALGIA SYNDROME | ASTRAZENECA AB (SE) | 2003-04-24 | — | — | WO | disclosed |
| US-20030008867-A1 | Compounds | ASTRAZENECA AB (SE) | 2003-01-09 | — | — | US | disclosed |
| EP-1259508-A1 | NOVEL BIARYLCARBOXAMIDES | AstraZeneca AB (SE) | 2002-11-27 | — | — | EP | disclosed |
| WO-2001060821-A1 | NOVEL BIARYLCARBOXAMIDES | ASTRAZENECA AB (SE) | 2001-08-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030008867-A1 | Compounds | DRD2, DRD1, GRIN2A | CHRNA7 209/4885HTR3E 350/4885HTR3B 441/4885 |
| US-20040259909-A1 | Treatment of fibromyalgia syndrome | CHRNA7, CHRNA5, CHRNA10 | CHRNA7 1/4885HTR3E 251/4885HTR3B 111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.