Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 12/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20521813 | 0.88 | MAPT (0.52) | MEN1ALDH1A1MAPTMAPK1KMT2A | |
| Hydrochloric Acid SCHEMBL31247929 | 0.84 | PTPN2 (0.39) | MEN1ALDH1A1MAPTMAPK1KMT2A | |
| SCHEMBL5556428 | 0.82 | PARP1 (0.48) | MEN1ALDH1A1MAPTMAPK1KMT2A | |
| SCHEMBL17164879 | 0.81 | MAPT (0.44) | MEN1ALDH1A1MAPTMAPK1KMT2A | |
| SCHEMBL31079000 | 0.74 | IKBKB (0.40) | MAPK10PARP1CDC7IKBKBCHUK | |
| SCHEMBL2555585 | 0.73 | MAPK10 (0.38) | MEN1ALDH1A1MAPTMAPK1KMT2A | |
| SCHEMBL23413476 | 0.72 | PTPN2 (0.46) | MEN1ALDH1A1MAPTMAPK1KMT2A | |
| SCHEMBL28325510 | 0.71 | PARP1 (0.57) | PARP1CDC7IKBKBCHUKPARP2 | |
| SCHEMBL2550311 | 0.70 | ABCC1 (0.38) | MEN1ALDH1A1MAPTMAPK1KMT2A | |
| SCHEMBL14862766 | 0.70 | MAPK10 (0.40) | MEN1ALDH1A1MAPTMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090054396-A1 | SUBSTITUTED THIOPHENES AND USES THEREOF | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | US | disclosed |
| US-7423061-B2 | Substitute thiophenes and uses thereof | ASTRAZENECA AB (SE) | 2008-09-09 | — | — | US | disclosed |
| US-20060281666-A1 | Substitute thiophenes and uses therof | ASTRAZENECA AB (SE) | 2006-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054396-A1 | SUBSTITUTED THIOPHENES AND USES THEREOF | TPMT, ABCG2, TYMP | MEN1 1076/4885ALDH1A1 266/4885MAPT 2490/4885 |
| US-20060281666-A1 | Substitute thiophenes and uses therof | TYMP, TPMT, MGMT | MEN1 1011/4885ALDH1A1 876/4885MAPT 1633/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.