Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 13/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4196361 | 0.92 | PTGER4 (0.39) | PTGER4PTGS1CYP1A2CYP2D6AKR1C3 | |
| SCHEMBL2298376 | 0.88 | PTGER4 (0.44) | PTGER4PTGS2PTGS1CYP1A2CYP2D6 | |
| SCHEMBL2429847 | 0.86 | PTGER4 (0.43) | PTGER4CYP1A2CYP2D6AKR1C3AKR1C2 | |
| SCHEMBL2937290 | 0.83 | PTGER4 (0.58) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL2937634 | 0.83 | PTGER4 (0.58) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL1591302 | 0.83 | PTGER4 (0.41) | PTGER4PTGS2PTGS1CYP1A2CYP2D6 | |
| SCHEMBL1590458 | 0.83 | PTGER4 (0.40) | PTGER4PTGS2PTGS1CYP1A2CYP2D6 | |
| SCHEMBL3230613 | 0.81 | PTGER4 (0.39) | PTGER4PTGS1CYP1A2CYP2D6 | |
| SCHEMBL2295950 | 0.81 | AKR1C3 (0.38) | PTGER4PTGS2PTGS1AKR1C3AKR1C2 | |
| SCHEMBL2435918 | 0.80 | PTGER4 (0.49) | PTGER4CYP1A2CYP2D6AKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090312388-A1 | Benzo [F] Isoindoles As EP4 Receptor Agonists | GLAXO GROUP LIMITED | 2009-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312388-A1 | Benzo [F] Isoindoles As EP4 Receptor Agonists | PTGER4, GPR4, PTGER1 | PTGER4 1/4885PTGS2 185/4885PTGS1 168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.