Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 8/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3421217 | 0.87 | ALDH1A1 (0.57) | STAT3MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL3434519 | 0.86 | MEN1 (0.61) | STAT3MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL13337855 | 0.86 | STAT3 (0.60) | STAT3MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL3423136 | 0.86 | MEN1 (0.56) | STAT3MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL3423140 | 0.86 | MEN1 (0.56) | STAT3MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL3351954 | 0.86 | MEN1 (0.52) | STAT3MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL3351943 | 0.86 | MEN1 (0.52) | STAT3MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL3418587 | 0.86 | ALDH1A1 (0.56) | STAT3MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL3421618 | 0.85 | ALDH1A1 (0.63) | STAT3MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL3432855 | 0.84 | MEN1 (0.58) | STAT3MEN1KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7714134-B2 | Compounds and use of tetrahydropyridothiophenes | 4SC AG (DE) | 2010-05-11 | — | — | US | disclosed |
| US-7714134-B2 | Compounds and use of tetrahydropyridothiophenes | 4SC AG (DE) | 2010-05-11 | — | — | US | disclosed |
| US-20090209534-A1 | NOVEL COMPOUNDS AND USE OF TETRAHYDROPYRIDOPYRIDOTHIOPHENES | PEKARI KLAUS | 2009-08-20 | — | — | US | disclosed |
| US-20090209534-A1 | NOVEL COMPOUNDS AND USE OF TETRAHYDROPYRIDOPYRIDOTHIOPHENES | PEKARI KLAUS | 2009-08-20 | — | — | US | disclosed |
| EP-1463728-B1 | FUSED CYCLIC MODULATORS OF NUCLEAR HORMONE RECEPTOR FUNCTION | BRISTOL MYERS SQUIBB CO (US) | 2009-01-14 | — | — | EP | disclosed |
| US-20070259911-A1 | Novel Compounds and Use of Tetrahydropyridothiophenes | NYCOMED GMBH (DE) | 2007-11-08 | — | — | US | disclosed |
| US-20070259911-A1 | Novel Compounds and Use of Tetrahydropyridothiophenes | NYCOMED GMBH (DE) | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209534-A1 | NOVEL COMPOUNDS AND USE OF TETRAHYDROPYRIDOPYRIDOTHIOPHENES | RB1, MCL1, CCAR2 | STAT3 357/4885MEN1 3560/4885KMT2A 2457/4885 |
| US-20070259911-A1 | Novel Compounds and Use of Tetrahydropyridothiophenes | RB1, BAX, BCL2 | STAT3 268/4885MEN1 3291/4885KMT2A 2718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.