Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of (+)-Pentazocine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 9/20 | 0.83 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.83 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.83 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.83 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.83 |
| ▸ | EBP | Q15125 | 2/20 | 0.83 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pentazocine SCHEMBL16107180 | 1.00 | SIGMAR1 (0.83) | SIGMAR1OPRM1OPRD1OPRK1TMEM97 | |
| (+)-Pentazocine SCHEMBL3665045 | 1.00 | SIGMAR1 (0.83) | SIGMAR1OPRM1OPRD1OPRK1TMEM97 | |
| Pentazocine SCHEMBL7865847 | 0.94 | SIGMAR1 (0.83) | SIGMAR1OPRM1OPRD1OPRK1TMEM97 | |
| Rel-Pentazocine SCHEMBL135685 | 0.91 | SIGMAR1 (1.00) | SIGMAR1OPRM1OPRD1OPRK1TMEM97 | |
| (+)-Pentazocine SCHEMBL680675 | 0.91 | SIGMAR1 (1.00) | SIGMAR1OPRM1OPRD1OPRK1TMEM97 | |
| Pentazocine SCHEMBL2493 | 0.91 | SIGMAR1 (1.00) | SIGMAR1OPRM1OPRD1OPRK1TMEM97 | |
| (+)-Pentazocine SCHEMBL4376337 | 0.91 | SIGMAR1 (1.00) | SIGMAR1OPRM1OPRD1OPRK1TMEM97 | |
| (+)-Pentazocine SCHEMBL16220021 | 0.91 | SIGMAR1 (1.00) | SIGMAR1OPRM1OPRD1OPRK1TMEM97 | |
| (+)-Pentazocine SCHEMBL22865258 | 0.91 | SIGMAR1 (1.00) | SIGMAR1OPRM1OPRD1OPRK1TMEM97 | |
| (+)-Pentazocine SCHEMBL18672553 | 0.91 | SIGMAR1 (1.00) | SIGMAR1OPRM1OPRD1OPRK1TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3850 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023210944-A1 | LATERAL FLOW ASSAY STRIP FOR DETECTING DRUGS USING DRUG DETECTION REAGENT, AND MANUFACTURING METHOD THEREFOR | 주식회사 필메디 | 2023-11-02 | — | — | WO | claimed |
| CN-115737571-A | Pentazocine preparation and preparation method and application thereof | 广州市力鑫药业有限公司 | 2023-03-07 | — | — | CN | claimed |
| US-10925864-B2 | Stable liquid injectable solution of midazolam and pentazocine | NEON LABORATORIES LIMITED (IN) | 2021-02-23 | — | — | US | claimed |
| WO-2019170059-A1 | METHOD FOR ENCAPSULATING DRUG WITHIN FERRITIN, AND PRODUCT THEREOF | 昆山新蕴达生物科技有限公司 | 2019-09-12 | — | — | WO | claimed |
| CN-102014975-A | Gradient Coatings for Biomedical Applications | SMITH & NEPHEW INC | 2011-04-13 | — | — | CN | claimed |
| EP-2259805-A2 | GRADIENT COATING FOR BIOMEDICAL APPLICATIONS | Smith & Nephew, Inc. (US) | 2010-12-15 | — | — | EP | claimed |
| WO-2009111300-A2 | GRADIENT COATING FOR BIOMEDICAL APPLICATIONS | SMITH & NEPHEW, INC. (US) | 2009-09-11 | — | — | WO | claimed |
| WO-2008116165-A9 | METHODS AND SYSTEMS OF DELIVERING MEDICATION VIA INHALATION | NEXT SAFETY INC (US) | 2009-06-11 | — | — | WO | claimed |
| JP-4256259-B2 | — | — | 2009-04-22 | — | — | JP | claimed |
| WO-2008116165-A2 | METHODS AND SYSTEMS OF DELIVERING MEDICATION VIA INHALATION | NEXT SAFETY, INC. (US) | 2008-09-25 | — | — | WO | claimed |
| EP-1416920-A4 | MULTIPLEX DRUG DELIVERY SYSTEM SUITABLE FOR ORAL ADMINISTRATION | IMPAX PHARMACEUTICALS INC (US) | 2004-05-12 | — | — | EP | claimed |
| US-6730321-B2 | FOR TABLETS; COMPRESSION BLEND; SUSTAINED RELEASE | IMPAX PHARMACEUTICALS, INC. | 2004-05-04 | — | — | US | claimed |
| US-20030203028-A1 | Multiplex drug delivery system suitable for oral administration | IMPAX PHARMACEUTICALS, INC. | 2003-10-30 | — | — | US | claimed |
| WO-2003007802-A9 | PHARMACEUTICAL COMBINATIONS OF OXYCODONE AND NALOXONE | EURO CELTIQUE SA (LU) | 2003-10-16 | — | — | WO | claimed |
| WO-2003007802-A2 | PHARMACEUTICAL COMBINATIONS OF OXYCODONE AND NALOXONE | EURO-CELTIQUE, S.A. (LU) | 2003-01-30 | — | — | WO | claimed |
| US-20020164371-A1 | Press coated, pulsatile drug delivery system suitable for oral administration | IMPAX PHARMACEUTICALS INC. | 2002-11-07 | — | — | US | claimed |
| US-6372254-B1 | Press coated, pulsatile drug delivery system suitable for oral administration | IMPAX PHARMACEUTICALS INC. | 2002-04-16 | — | — | US | claimed |
| WO-2000018447-A2 | MULTIPLEX DRUG DELIVERY SYSTEM SUITABLE FOR ORAL ADMINISTRATION | IMPAX PHARMACEUTICALS, INC. (US) | 2000-04-06 | — | — | WO | claimed |
| WO-1999051209-A1 | PRESS COATED, PULSATILE DRUG DELIVERY SYSTEM SUITABLE FOR ORAL ADMINISTRATION | IMPAX PHARMACEUTICALS, INC. (US) | 1999-10-14 | — | — | WO | claimed |
| US-4126684-A | 4-AMINO-3-P-HALOPHENYLBUTYRIC ACIDS AND THEIR DERIVATIVES USED IN THE CONTROL OF NARCOTIC ABUSE | CIBA-GEIGY CORPORATION (US) | 1978-11-21 | — | — | US | claimed |