Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 10/20 | 0.53 |
| ▸ | GHSR | Q92847 | 2/20 | 0.46 |
| ▸ | TYMS | P04818 | 1/20 | 0.45 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | HTR5A | P47898 | 1/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1380082 | 0.92 | HTR6 (0.46) | HTR6GHSRTYMSHTR3EHTR3B | |
| SCHEMBL3626769 | 0.87 | HTR6 (0.48) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL3620770 | 0.85 | HTR6 (0.41) | HTR6GHSRTYMSCYP1A2HTR1A | |
| SCHEMBL3619404 | 0.85 | HTR6 (0.49) | HTR6GHSRHTR1AHTR1DHTR1B | |
| SCHEMBL3622734 | 0.84 | HTR6 (0.55) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| Hydrochloric Acid SCHEMBL1377178 | 0.83 | HTR6 (0.54) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL1378277 | 0.82 | LRRK2 (0.39) | HTR6CYP1A2HTR1ACYP2D6HTR1D | |
| SCHEMBL3620585 | 0.79 | HTR6 (0.49) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL3614689 | 0.79 | HTR6 (0.53) | HTR6HTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL3612342 | 0.79 | HTR6 (0.43) | HTR6CYP2D6KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896460-B1 | BENZOFURANYL DERIVATIVES AS 5-HT6-RECEPTOR INHIBITORS | BIOVITRUM AB PUBL (SE) | 2009-07-22 | — | — | EP | disclosed |
| EP-1896460-A1 | BENZOFURANYL DERIVATIVES AS 5-HT6-RECEPTOR INHIBITORS | Biovitrum AB (publ) (SE) | 2008-03-12 | — | — | EP | disclosed |
| WO-2006134150-A1 | BENZOFURANYL DERIVATIVES AS 5-HT6-RECEPTOR INHIBITORS | BIOVITRUM AB (PUBL) (SE) | 2006-12-21 | — | — | WO | disclosed |