Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 17/20 | 0.41 |
| ▸ | LYN | P07948 | 17/20 | 0.41 |
| ▸ | SRC | P12931 | 17/20 | 0.41 |
| ▸ | KDR | P35968 | 17/20 | 0.41 |
| ▸ | INSR | P06213 | 15/20 | 0.41 |
| ▸ | HCK | P08631 | 14/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ADCY8 | P40145 | 1/20 | 0.36 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3577332 | 0.81 | LCK (0.56) | LCKLYNSRCKDRINSR | |
| SCHEMBL3593435 | 0.78 | POLB (0.59) | LCKLYNSRCKDRINSR | |
| SCHEMBL3587207 | 0.78 | KDR (0.56) | LCKLYNSRCKDRINSR | |
| SCHEMBL3587554 | 0.76 | POLB (0.45) | LCKLYNSRCKDRINSR | |
| SCHEMBL3594090 | 0.76 | LCK (0.50) | LCKLYNSRCKDRINSR | |
| SCHEMBL3589488 | 0.75 | BRAF (0.47) | LCKLYNSRCKDRINSR | |
| SCHEMBL3598038 | 0.75 | CSF1R (0.48) | LCKLYNSRCKDRINSR | |
| SCHEMBL3588148 | 0.75 | BRAF (0.48) | LCKLYNSRCKDRINSR | |
| SCHEMBL14219021 | 0.75 | KDR (0.49) | LCKLYNSRCKDRINSR | |
| SCHEMBL3588537 | 0.74 | INSR (0.49) | LCKLYNSRCKDRINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057146-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-05-13 | — | — | EP | claimed |
| WO-2008042639-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-04-10 | — | — | WO | claimed |
| EP-2057146-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008042639-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-04-10 | — | — | WO | disclosed |