Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 4/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.38 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20571510 | 0.85 | KDM1A (0.41) | KDM1ABCHENISCHGRIA1GRIA2 | |
| SCHEMBL30479618 | 0.85 | KDM1A (0.41) | KDM1ABCHENISCHGRIA1GRIA2 | |
| Hydrochloric Acid SCHEMBL31477155 | 0.83 | KDM1A (0.41) | KDM1ABCHENISCHGRIA1GRIA2 | |
| SCHEMBL18496369 | 0.79 | KDM1A (0.48) | KDM1ANUDT1 | |
| SCHEMBL4366358 | 0.78 | PARP1 (0.42) | KDM1ABCHEGRIA1GRIA2GRIA3 | |
| SCHEMBL14785203 | 0.77 | PARP10 (0.51) | BCHENISCHGRIA1GRIA2GRIA3 | |
| SCHEMBL1632063 | 0.76 | PNMT (0.42) | KDM1ABCHEGRIA1GRIA2GRIA3 | |
| SCHEMBL326944 | 0.74 | NOTUM (0.41) | KDM1ANISCHPARP1TSHR | |
| SCHEMBL4206469 | 0.74 | BCHE (0.39) | KDM1ABCHEGRIA1GRIA2GRIA3 | |
| SCHEMBL24286919 | 0.74 | ESR2 (0.43) | ESR2USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2034998-A1 | 1,2,3,4-TETRAHYDRO-QUINOLINE DERIVATIVES AS CETP INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2008079427-A1 | 1,2,3,4-TETRAHYDRO-QUINOLINE DERIVATIVES AS CETP INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-03 | — | — | WO | disclosed |