Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | KDM1A | O60341 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | CTSA | P10619 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | GCGR | P47871 | 2/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4218916 | 0.82 | CYP4F2 (0.49) | MAPK1DYRK1APDE10AALPLMET | |
| SCHEMBL18914426 | 0.78 | MAPK1 (0.47) | MAPK1CYP46A1DYRK1APDE10AALPL | |
| SCHEMBL13680499 | 0.77 | MAPK1 (0.51) | MAPK1DYRK1AEGLN1KDM4EL3MBTL1 | |
| SCHEMBL82621 | 0.77 | MAPK1 (0.67) | MAPK1DYRK1APDE10AKDM4EL3MBTL1 | |
| SCHEMBL29565067 | 0.77 | MAPK1 (0.67) | MAPK1DYRK1APDE10AKDM4EL3MBTL1 | |
| SCHEMBL18848887 | 0.77 | PDE3B (0.53) | HDAC6CTSAPDGFRB | |
| SCHEMBL8258906 | 0.77 | MAPK1 (0.54) | MAPK1DYRK1AKDM4EL3MBTL1HPGD | |
| SCHEMBL20862077 | 0.75 | GCGR (0.40) | HDAC1KDM1AHDAC6CTSAGCGR | |
| SCHEMBL38655111 | 0.75 | MAPK1 (0.49) | MAPK1DYRK1AKDM4EL3MBTL1HPGD | |
| SCHEMBL28773890 | 0.75 | CTSA (0.43) | HDAC1KDM1AHDAC6CTSADHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221547-A1 | Immunosuppressant Compounds and Compositions | IRM LLC (BM) | 2009-09-03 | — | — | US | disclosed |
| US-20090221547-A1 | Immunosuppressant Compounds and Compositions | IRM LLC (BM) | 2009-09-03 | — | — | US | disclosed |
| US-20090221547-A1 | Immunosuppressant Compounds and Compositions | IRM LLC (BM) | 2009-09-03 | — | — | US | disclosed |
| EP-1917240-A1 | IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS | IRM LLC (BM) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007024922-A1 | IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS | IRM LLC (BM) | 2007-03-01 | — | — | WO | disclosed |
| WO-2007024922-A1 | IMMUNOSUPPRESSANT COMPOUNDS AND COMPOSITIONS | IRM LLC (BM) | 2007-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221547-A1 | Immunosuppressant Compounds and Compositions | ICOS, EDNRA, ICOSLG | MAPK1 1125/4885CYP46A1 1400/4885HDAC1 2194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.