Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | WNT3A | P56704 | 1/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23380565 | 0.84 | MAPT (0.51) | MAPK1CYP4F2CYP4A11DYRK1ACDK8 | |
| SCHEMBL13680500 | 0.83 | KMO (0.57) | CYP4F2CYP4A11MEN1ALDH1A1LMNA | |
| SCHEMBL11041168 | 0.83 | MAPK1 (0.59) | MAPK1DYRK1AMEN1KMT2AKDM4E | |
| SCHEMBL24061023 | 0.82 | PIP5K1C (0.53) | MEN1ALDH1A1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL23201168 | 0.82 | ALDH1A1 (0.51) | HSD17B10ALDH1A1KMT2ASMN1; SMN2WNT3A | |
| SCHEMBL22070487 | 0.82 | CYP4F2 (0.66) | CYP4F2CYP4A11HSD17B10ALDH1A1KMT2A | |
| SCHEMBL14875853 | 0.82 | RXRA (0.50) | MAPK1CYP4F2CYP4A11DYRK1ACDK8 | |
| SCHEMBL21044529 | 0.80 | SMN1; SMN2 (0.49) | HSD17B10MEN1ALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL13680554 | 0.78 | GRM5 (0.53) | MAPK1DYRK1AMEN1KMT2AKDM4E | |
| SCHEMBL11049832 | 0.78 | NOTUM (0.59) | MAPK1DYRK1AKMOKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |