Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.57 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.57 |
| ▸ | AR | P10275 | 5/20 | 0.56 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4214482 | 1.00 | GRM2 (0.57) | GRM2GRM3ARBCHEACHE | |
| SCHEMBL13651271 | 0.92 | GRM2 (0.53) | GRM2GRM3ARBCHEACHE | |
| Hydrochloric Acid SCHEMBL4215940 | 0.91 | GRM2 (0.52) | GRM2GRM3ARBCHEACHE | |
| Hydrochloric Acid SCHEMBL4215931 | 0.91 | GRM2 (0.52) | GRM2GRM3ARBCHEACHE | |
| Hydrochloric Acid SCHEMBL4219962 | 0.91 | GRM2 (0.52) | GRM2GRM3ARBCHEACHE | |
| Hydrochloric Acid SCHEMBL4219956 | 0.91 | GRM2 (0.52) | GRM2GRM3ARBCHEACHE | |
| SCHEMBL13651269 | 0.91 | GRM2 (0.54) | GRM2GRM3ARBCHEACHE | |
| Hydrochloric Acid SCHEMBL4228675 | 0.90 | GRM2 (0.53) | GRM2GRM3ARBCHEACHE | |
| Hydrochloric Acid SCHEMBL4228676 | 0.90 | GRM2 (0.53) | GRM2GRM3ARBCHEACHE | |
| SCHEMBL13651262 | 0.88 | GRM2 (0.58) | GRM2GRM3ARBCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805165-B1 | 1-(HETERO)ARYL-3-AMINO-PYRROLIDINE DERIVATIVES FOR USE AS MGLUR3 RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2009-12-16 | — | — | EP | disclosed |