Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 10/20 | 0.74 |
| ▸ | TLR9 | Q9NR96 | 10/20 | 0.69 |
| ▸ | TLR8 | Q9NR97 | 10/20 | 0.69 |
| ▸ | BTK | Q06187 | 4/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | MTOR | P42345 | 2/20 | 0.39 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.39 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.39 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.39 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | HCK | P08631 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4214625 | 0.91 | TLR7 (0.74) | TLR7TLR9TLR8BTKPIK3CA | |
| SCHEMBL4228277 | 0.91 | TLR7 (0.70) | TLR7TLR9TLR8PIK3CAMTOR | |
| SCHEMBL4044815 | 0.90 | TLR7 (0.72) | TLR7TLR9TLR8PIK3CAMTOR | |
| SCHEMBL4275196 | 0.89 | TLR7 (0.74) | TLR7TLR9TLR8BTKPIK3CA | |
| SCHEMBL4226497 | 0.87 | TLR7 (0.79) | TLR7TLR9TLR8BTK | |
| SCHEMBL4047282 | 0.86 | TLR7 (0.67) | TLR7TLR9TLR8PIK3CAMTOR | |
| SCHEMBL4046635 | 0.86 | TLR7 (0.67) | TLR7TLR9TLR8PIK3CAMTOR | |
| SCHEMBL4221225 | 0.85 | TLR7 (1.00) | TLR7TLR9TLR8KDR | |
| SCHEMBL4223404 | 0.84 | TLR7 (0.75) | TLR7TLR9TLR8KDM4E | |
| SCHEMBL4219300 | 0.84 | TLR7 (0.65) | TLR7TLR9TLR8KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2026811-A1 | PYRAZOLO [3, 4-D]PYRIMIDINE DERIVATIVES USEFUL TO TREAT RESPIRATORY DISORDERS | Novartis AG (CH) | 2009-02-25 | — | — | EP | disclosed |
| WO-2007134828-A1 | PYRAZOLO [3, 4-D] PYRIMIDINE DERIVATIVES USEFUL TO TREAT RESPIRATORY DISORDERS | NOVARTIS AG (CH) | 2007-11-29 | — | — | WO | disclosed |