Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 9/20 | 0.74 |
| ▸ | TLR9 | Q9NR96 | 9/20 | 0.69 |
| ▸ | TLR8 | Q9NR97 | 9/20 | 0.69 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.40 |
| ▸ | FEN1 | P39748 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 2/20 | 0.38 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.38 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.38 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.38 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.37 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.37 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.37 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4214625 | 0.96 | TLR7 (0.74) | TLR7TLR9TLR8ALOX5APFEN1 | |
| SCHEMBL4215022 | 0.89 | TLR7 (0.74) | TLR7TLR9TLR8PIK3CAMTOR | |
| SCHEMBL4044815 | 0.88 | TLR7 (0.72) | TLR7TLR9TLR8PIK3CAMTOR | |
| SCHEMBL4228277 | 0.87 | TLR7 (0.70) | TLR7TLR9TLR8PIK3CAMTOR | |
| SCHEMBL4221225 | 0.85 | TLR7 (1.00) | TLR7TLR9TLR8HRH3 | |
| SCHEMBL4226497 | 0.85 | TLR7 (0.79) | TLR7TLR9TLR8BTKHRH3 | |
| SCHEMBL4047282 | 0.85 | TLR7 (0.67) | TLR7TLR9TLR8PIK3CAMTOR | |
| SCHEMBL4046635 | 0.84 | TLR7 (0.67) | TLR7TLR9TLR8ALOX5APFEN1 | |
| SCHEMBL4221994 | 0.84 | TLR7 (0.83) | TLR7TLR9TLR8KDM4EEGFR | |
| SCHEMBL4219300 | 0.82 | TLR7 (0.65) | TLR7TLR9TLR8KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160303132-A1 | PYRAZOLO [3,4-D] PYRIMIDINE DERIVATIVES USEFUL TO TREAT RESPIRATORY DISORDERS | NOVARTIS AG (CH) | 2016-10-20 | — | — | US | claimed |
| US-20180125849-A1 | PYRAZOLO [3,4-D] PYRIMIDINE DERIVATIVES USEFUL TO TREAT RESPIRATORY DISORDERS | NOVARTIS AG (CH) | 2018-05-10 | — | — | US | disclosed |
| US-20160303132-A1 | PYRAZOLO [3,4-D] PYRIMIDINE DERIVATIVES USEFUL TO TREAT RESPIRATORY DISORDERS | NOVARTIS AG (CH) | 2016-10-20 | — | — | US | disclosed |
| US-8901134-B2 | Pyrazolo [3,4-D] pyrimidine derivatives useful to treat respiratory disorders | NOVARTIS AG (CH) | 2014-12-02 | — | — | US | disclosed |
| US-20140235632-A1 | PYRAZOLO [3,4-D] PYRIMIDINE DERIVATIVES USEFUL TO TREAT RESPIRATORY DISORDERS | NOVARTIS AG (CH) | 2014-08-21 | — | — | US | disclosed |
| US-20140051698-A1 | Pyrazolo [3,4-D] Pyrimidine Derivatives Useful to Treat Respiratory Disorders | NOVARTIS AG (CH) | 2014-02-20 | — | — | US | disclosed |
| US-20090131457-A1 | Pyrazolo [3,4-D] Pyrimidine Derivatives Useful to Treat Respiratory Disorders | NOVARTIS AG (CH) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131457-A1 | Pyrazolo [3,4-D] Pyrimidine Derivatives Useful to Treat Respiratory Disorders | PIK3CA, JAK3, PDK1 | TLR7 1301/4885TLR9 1750/4885TLR8 2531/4885 |
| US-20140051698-A1 | Pyrazolo [3,4-D] Pyrimidine Derivatives Useful to Treat Respiratory Disorders | PIK3CA, JAK3, PDK1 | TLR7 1301/4885TLR9 1750/4885TLR8 2531/4885 |
| US-20160303132-A1 | PYRAZOLO [3,4-D] PYRIMIDINE DERIVATIVES USEFUL TO TREAT RESPIRATORY DISORDERS | PIK3CA, JAK3, PDK1 | TLR7 1301/4885TLR9 1750/4885TLR8 2531/4885 |
| US-20140235632-A1 | PYRAZOLO [3,4-D] PYRIMIDINE DERIVATIVES USEFUL TO TREAT RESPIRATORY DISORDERS | PIK3CA, JAK3, PDK1 | TLR7 1301/4885TLR9 1750/4885TLR8 2531/4885 |
| US-20180125849-A1 | PYRAZOLO [3,4-D] PYRIMIDINE DERIVATIVES USEFUL TO TREAT RESPIRATORY DISORDERS | PIK3CA, JAK3, PDK1 | TLR7 1301/4885TLR9 1750/4885TLR8 2531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.