⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22472150 | 1.00 | TRPV1 (0.40) | — | |
| SCHEMBL21694380 | 1.00 | TRPV1 (0.40) | — | |
| SCHEMBL6434209 | 1.00 | TRPV1 (0.40) | — | |
| SCHEMBL6440333 | 1.00 | TRPV1 (0.40) | — | |
| SCHEMBL7862202 | 1.00 | TRPV1 (0.40) | — | |
| SCHEMBL6440275 | 1.00 | TRPV1 (0.40) | — | |
| SCHEMBL21694371 | 1.00 | TRPV1 (0.40) | — | |
| SCHEMBL423131 | 0.97 | — | — | |
| SCHEMBL755558 | 0.88 | — | — | |
| SCHEMBL27904586 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 300 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9556155-B2 | Methods of treating fatty liver disease | GENZYME CORPORATION (US) | 2017-01-31 | — | — | US | claimed |
| US-9532976-B2 | Method of lowering blood glucose | GENZYME CORPORATION (US) | 2017-01-03 | — | — | US | claimed |
| EP-2923699-A1 | METHODS OF TREATING FATTY LIVER DISEASE | Genzyme Corporation (US) | 2015-09-30 | — | — | EP | claimed |
| US-20150190373-A1 | Method of Treating Diabetes Mellitus | GENZYME CORPORATION | 2015-07-09 | — | — | US | claimed |
| EP-2032134-B1 | METHODS OF TREATING FATTY LIVER DISEASE COMPRISING INHIBITING GLUCOSPHINGOLIPID SYNTHESIS | GENZYME CORP (US) | 2015-06-24 | — | — | EP | claimed |
| US-20150051261-A1 | Methods of Treating Fatty Liver Disease | GENZYME CORPORATION (US) | 2015-02-19 | — | — | US | claimed |
| US-8716327-B2 | Methods of treating fatty liver disease | GENZYME CORPORATION (US) | 2014-05-06 | — | — | US | claimed |
| US-20120022126-A1 | Method Of Treating Diabetes Mellitus | GENZYME CORPORATION (US) | 2012-01-26 | — | — | US | claimed |
| US-8003617-B2 | e.g. 1-(3',4'-ethylenedioxy)phenyl-2-nonanoylamino-3-pyrrolidino-1-propanol; glucosylceramide synthase inhibitor; inhibits glycosphingolipid synthesis; antidiabetic, hypoglycemic agent; non-insulin dependent diabetes, obesity, Gaucher's disease | GENZYME CORPORATION (US) | 2011-08-23 | — | — | US | claimed |
| US-20090105125-A1 | Methods of Treating Fatty Liver Disease | GENZYME CORPORATION | 2009-04-23 | — | — | US | claimed |
| EP-1811991-A2 | METHODS OF TREATING DIABETES MELLITUS | Genzyme Corporation (US) | 2007-08-01 | — | — | EP | claimed |
| WO-2006053043-A2 | METHODS OF TREATING DIABETES MELLITUS | GENZYME CORPORATION (US) | 2006-05-18 | — | — | WO | claimed |
| EP-0584347-B1 | ENANTIOMERIC HYDROXYLATED XANTHINE COMPOUNDS | CELL THERAPEUTICS INC (US) | 2003-01-15 | — | — | EP | claimed |
| CN-1040646-C | Enatiomeric hydroxylated xanthine compounds | CELL THERAPEUTICS INC (US) | 1998-11-11 | — | — | CN | claimed |
| US-5648357-A | MAINTAINING HOMEOSTASIS IN RESPONSE TO INFLAMMATORY AND PROLIFERATIVE STIMULI | CELL THERAPEUTICS, INC. (US) | 1997-07-15 | — | — | US | claimed |
| EP-0584347-A4 | ENANTIOMERIC HYDROXYLATED XANTHINE COMPOUNDS. | CELL THERAPEUTICS INC (US) | 1995-04-26 | — | — | EP | claimed |
| US-5321057-A | Ammonium polyphosphate microencapsulated with aminoplastic resins | MINISTERO DELL'UNIVERSITA' E DELLA RICERCA SCIENTIFICA E TECNOLOGICA (IT) | 1994-06-14 | — | — | US | claimed |
| CN-1085557-A | The enantiomorph hydroxylated xanthine compounds | CELL THERAPEUTICS INC (US) | 1994-04-20 | — | — | CN | claimed |
| EP-0584347-A1 | ENANTIOMERIC HYDROXYLATED XANTHINE COMPOUNDS | CELL THERAPEUTICS, INC. (US) | 1994-03-02 | — | — | EP | claimed |
| WO-1993017684-A2 | ENANTIOMERIC HYDROXYLATED XANTHINE COMPOUNDS | CELL THERAPEUTICS, INC. (US) | 1993-09-16 | — | — | WO | claimed |