Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 4/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21347987 | 0.85 | CA12 (0.47) | CYP1A2CYP3A4CA12CA4CA7 | |
| SCHEMBL22793508 | 0.83 | TTR (0.43) | CYP1A2CYP3A4CYP2D6CA12CA4 | |
| SCHEMBL25745 | 0.80 | CA12 (0.44) | CYP1A2CA12CA4CA7CA9 | |
| SCHEMBL29358898 | 0.80 | CA12 (0.44) | CYP1A2CA12CA4CA7CA9 | |
| SCHEMBL29355645 | 0.80 | CA12 (0.44) | CYP1A2CA12CA4CA7CA9 | |
| SCHEMBL21347989 | 0.80 | CA12 (0.47) | CYP1A2CYP3A4CA12CA4CA7 | |
| SCHEMBL9626308 | 0.80 | CA12 (0.44) | CYP1A2CA12CA4CA7CA9 | |
| SCHEMBL22793503 | 0.80 | CYP1A2 (0.43) | CYP1A2CA12CA4CA7CA9 | |
| SCHEMBL134374 | 0.78 | CA12 (0.47) | CYP1A2CYP3A4CYP2D6CA12CA4 | |
| SCHEMBL6128009 | 0.77 | CA12 (0.63) | CYP1A2CYP3A4CYP2D6CA12CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023725-A1 | Fused Heteroaryl Derivatives for Use as P38 Kinase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2009-01-22 | — | — | US | claimed |
| EP-1708996-B1 | FUSED HETEROYRAL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2008-08-27 | — | — | EP | claimed |
| US-9725529-B2 | Compositions and methods for making and using multifunctional polymerized liposomes | UNIVERSITY OF HOUSTON (US) | 2017-08-08 | — | — | US | disclosed |
| US-20130324738-A1 | COMPOSITIONS AND METHODS FOR MAKING AND USING MULTIFUNCTIONAL POLYMERIZED LIPOSOMES | UNIVERSITY OF HOUSTON (US) | 2013-12-05 | — | — | US | disclosed |
| US-8506993-B2 | Compositions and methods for making and using multifunctional polymerized liposomes | UNIVERSITY OF HOUSTON (US) | 2013-08-13 | — | — | US | disclosed |
| US-20090162424-A1 | COMPOSITIONS AND METHODS FOR MAKING AND USING MULTIFUNCTIONAL POLYMERIZED LIPOSOMES | UNIVERSITY OF HOUSTON | 2009-06-25 | — | — | US | disclosed |
| US-20090023725-A1 | Fused Heteroaryl Derivatives for Use as P38 Kinase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2009-01-22 | — | — | US | disclosed |
| EP-1708996-B1 | FUSED HETEROYRAL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2008-08-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023725-A1 | Fused Heteroaryl Derivatives for Use as P38 Kinase Inhibitors | MAPK1, MAPKAPK2, MAPK7 | CYP1A2 1956/4885CYP3A4 3569/4885CYP2D6 2516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.